中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
34期
147-149,150
,共4页
新生婴儿%无乳链球菌%细菌性脑膜炎%预防性应用抗生素
新生嬰兒%無乳鏈毬菌%細菌性腦膜炎%預防性應用抗生素
신생영인%무유련구균%세균성뇌막염%예방성응용항생소
Newborn infant%Streptococcus agalactiae%Bacterial meningitis%Intrapartum antibiotic prophylaxis
目的：探讨新生儿无乳链球菌（GBS）败血症的临床特点并进行相关文献复习。方法：回顾性分析2012-2014年青岛市妇女儿童医院新生儿重症监护室住院的8例GBS败血症患儿的一般资料、临床特征、影像学检查结果、治疗及转归。结果：8例GBS败血症患儿4例为早发型，4例为晚发型；1例早产儿，7例足月顺产儿；7例发热伴不同程度的神经系统异常症状，1例无异常症状及体征，血培养均提示为青霉素及万古霉素敏感；5例合并化脓性脑膜炎，1例头颅MRI出现脑软化灶，2例蛛网膜下腔出血；影像学检查：2例MRI异常，4例正常，2例未做。随访至今，2例死亡，1例运动发育落后，5例生长发育正常。结论：新生儿GBS败血症死亡率、致残率高。强有力、足量、足疗程抗感染外，产前产时GBS筛查和预防性应用抗生素应积极尽早开展，以减少后遗症发生。
目的：探討新生兒無乳鏈毬菌（GBS）敗血癥的臨床特點併進行相關文獻複習。方法：迴顧性分析2012-2014年青島市婦女兒童醫院新生兒重癥鑑護室住院的8例GBS敗血癥患兒的一般資料、臨床特徵、影像學檢查結果、治療及轉歸。結果：8例GBS敗血癥患兒4例為早髮型，4例為晚髮型；1例早產兒，7例足月順產兒；7例髮熱伴不同程度的神經繫統異常癥狀，1例無異常癥狀及體徵，血培養均提示為青黴素及萬古黴素敏感；5例閤併化膿性腦膜炎，1例頭顱MRI齣現腦軟化竈，2例蛛網膜下腔齣血；影像學檢查：2例MRI異常，4例正常，2例未做。隨訪至今，2例死亡，1例運動髮育落後，5例生長髮育正常。結論：新生兒GBS敗血癥死亡率、緻殘率高。彊有力、足量、足療程抗感染外，產前產時GBS篩查和預防性應用抗生素應積極儘早開展，以減少後遺癥髮生。
목적：탐토신생인무유련구균（GBS）패혈증적림상특점병진행상관문헌복습。방법：회고성분석2012-2014년청도시부녀인동의원신생인중증감호실주원적8례GBS패혈증환인적일반자료、림상특정、영상학검사결과、치료급전귀。결과：8례GBS패혈증환인4례위조발형，4례위만발형；1례조산인，7례족월순산인；7례발열반불동정도적신경계통이상증상，1례무이상증상급체정，혈배양균제시위청매소급만고매소민감；5례합병화농성뇌막염，1례두로MRI출현뇌연화조，2례주망막하강출혈；영상학검사：2례MRI이상，4례정상，2례미주。수방지금，2례사망，1례운동발육락후，5례생장발육정상。결론：신생인GBS패혈증사망솔、치잔솔고。강유력、족량、족료정항감염외，산전산시GBS사사화예방성응용항생소응적겁진조개전，이감소후유증발생。
Objective:To explore clinical characteristics of neonatal group B streptococcal septicemia and do a literature review. Method:The general information,clinical features,imaging findings,treatment and prognosis of 8 neonates with GBS septicemia admitted to NICU of this hospital from 2012 to 2014 were analyzed retrospectively. Result:Among the 8 cases,4 cases were early-onset neonatal sepsis,4 cases were late-onset. 1 case was premature,7 cases were full-term. 7 cases had fever with different degrees of neurological abnormalities,1 had no abnormal symptoms and signs. All the GBS strains were sensitive to penicillin and vancomycin. 5 cases who had purulent meningitis were implemented the brain magnetic resonance imaging(MRI)before discharge,with the consequences of encephalodialysis in 1 case,subarachnoid hemorrhage in 2 cases.Imageological examination,2 cases of abnormal MRI 4 cases of normal and 2 cases not done. So far,the follow-up demonstrated that 2 neonates died,1 case had retardation,the other 5 cases were normal. Conclusion:Neonatal GBS septicemia had a high mortality and morbidity. It’s very necessary to develop the antepartum and intrapartum screening for GBS and the intrapartum antibiotic prophylaxis to reduce incidence of complications in addition to the strong,enough,full course of anti-infection treatment.
