CAJ | 학술논문

目的：分析初复治涂阳肺结核患者耐药情况，为有效控制耐药结核提供依据。方法收集我院2012年1月至2013年12月涂阳肺结核患者痰标本进行分离培养和菌种鉴定，用比例法进行药物敏感试验获得耐药情况。结果884例涂阳患者，832例培养阳性，结核分枝杆菌823例，非结核分枝杆菌9例，结核分枝杆菌总耐药率为33.2%，单耐药率为14.5%，多耐药率为6.0%，耐多药率为9.4%，广泛耐药率为3.4%，耐药顺位为异烟肼>链霉素>利福平>氧氟沙星>乙胺丁醇>左氧氟沙星>阿米卡星>卷曲霉素，初治耐多药率为5.0%，广泛耐药率为1.6%。复治耐多药发生率为25.4%，广泛耐药率为10.2%。结论徐州市传染病医院耐多药及广泛耐药肺结核患者在复治患者中比例较高，全程督导化疗政策的执行有待加强，尤其是耐多药及广泛耐药患者应重点管理。
목적：분석초복치도양폐결핵환자내약정황，위유효공제내약결핵제공의거。방법수집아원2012년1월지2013년12월도양폐결핵환자담표본진행분리배양화균충감정，용비례법진행약물민감시험획득내약정황。결과884례도양환자，832례배양양성，결핵분지간균823례，비결핵분지간균9례，결핵분지간균총내약솔위33.2%，단내약솔위14.5%，다내약솔위6.0%，내다약솔위9.4%，엄범내약솔위3.4%，내약순위위이연정>련매소>리복평>양불사성>을알정순>좌양불사성>아미잡성>권곡매소，초치내다약솔위5.0%，엄범내약솔위1.6%。복치내다약발생솔위25.4%，엄범내약솔위10.2%。결론서주시전염병의원내다약급엄범내약폐결핵환자재복치환자중비례교고，전정독도화료정책적집행유대가강，우기시내다약급엄범내약환자응중점관리。
Objective Analysis of drug resistance early retreatment smear positive pulmonary tuberculosis patients, provide the basis for effective control of drug-resistant TB. Methods Collected in our hospital from January 2012 to December 2013 in sputum smear positive pulmonary tuberculosis patients were isolated and cultured and strain identification,drug susceptibility testing method used to obtain the proportion of drug resistance. Results 884 cases of smear-positive patients with multi-drug culture positive rate of 832 cases, 823 cases of Mycobacterium tuberculosis, non-tuberculous mycobacteria nine cases, the total drug-resistant Mycobacterium tuberculosis was 33.2%, a single resistance rate of 14.5%, was 6.0%, 9.4% MDR, XDR was 3.4%, overall resistance to isoniazid> streptomycin> rifampicin> ofloxacin>ethambutol> levofloxacin> A Mika Star> capreomycin, initial treatment was 5.0% MDR, XDR rate of 1.6%. Retreatment MDR incidence of 25.4%, 10.2% XDR. Conclusions Xuzhou City Hospital for Infectious Diseases of multidrug-resistant and extensively drug-resistant tuberculosis patients in retreatment of patients with a higher proportion of full implementation of DOTS policy needs to be strengthened, especially in multi-drug resistant and extensively drug-resistant patients should focus on management.