CAJ | 학술논문

目的：探讨血清中可溶性血管内皮生长因子受体-1（sFlt-1）与妊娠期高血压疾病的关系。方法选择我院产科住院分娩的155例妊娠期高血压疾病患者作为病例组，选择同期113例正常妊娠妇女作为对照组，用酶联免疫吸附(ELISA)法检测两组孕妇血清sFlt-1水平，比较组间患者的一般情况,对妊娠期高血压疾病的危险因素进行单因素和多因素logistic回归分析。结果（1）妊娠期高血压疾病患者的sFlt-1、年龄、高血压家族史、产前体质指数、腹围、低密度脂蛋白，甘油三酯水平均高于对照组，而受教育程度、经济收入水平低于对照组，差异有统计学意义。（2）妊娠期高血压疾病患者各亚组比较：年龄、受教育程度、经济收入、高血压家族史、腹围、BMI、LDL- C、TG、空腹血糖均无统计学差异，sFlt-1浓度在三组间有逐渐增高的趋势，且轻、重度子痫前期组高于妊娠期高血压组，重度子痫前期组高于轻度子痫前期组，差异有统计学意义。（3）多因素logistic回归分析结果显示：sFlt-1、TG、FBG为妊娠期高血压疾病的危险因素，其OR值分别为1.058、8.619、1.479。结论（1）血清中sFlt-1水平增加是妊娠期高血压疾病的危险因素。（2）妊娠期高血压疾病患者有心血管疾病危险因素聚集。
목적：탐토혈청중가용성혈관내피생장인자수체-1（sFlt-1）여임신기고혈압질병적관계。방법선택아원산과주원분면적155례임신기고혈압질병환자작위병례조，선택동기113례정상임신부녀작위대조조，용매련면역흡부(ELISA)법검측량조잉부혈청sFlt-1수평，비교조간환자적일반정황,대임신기고혈압질병적위험인소진행단인소화다인소logistic회귀분석。결과（1）임신기고혈압질병환자적sFlt-1、년령、고혈압가족사、산전체질지수、복위、저밀도지단백，감유삼지수평균고우대조조，이수교육정도、경제수입수평저우대조조，차이유통계학의의。（2）임신기고혈압질병환자각아조비교：년령、수교육정도、경제수입、고혈압가족사、복위、BMI、LDL- C、TG、공복혈당균무통계학차이，sFlt-1농도재삼조간유축점증고적추세，차경、중도자간전기조고우임신기고혈압조，중도자간전기조고우경도자간전기조，차이유통계학의의。（3）다인소logistic회귀분석결과현시：sFlt-1、TG、FBG위임신기고혈압질병적위험인소，기OR치분별위1.058、8.619、1.479。결론（1）혈청중sFlt-1수평증가시임신기고혈압질병적위험인소。（2）임신기고혈압질병환자유심혈관질병위험인소취집。
Objective To investigate the relationship between the role of serum sFlt- 1 and HDCP. Methods 155 pregnancy women with HDCP in our hospital were enrolled in the case group,the control group included 113normal pregnant women during the same period . Serum levels of sFlt- 1 were determined by ELISA and clinical datas were compared between case and control groups. In the mean time, logistic regression was used to analyze the risk factors of HDCP.Results (1)The serum level of sFlt- 1 and patients age,high blood pressure family history, antepartum body mass index,abdomen circumference,LDL- C and TG of HDCP were significantly higher than that in control women ,The family income and educational level were lower in HDCP group compared with control women,such as. (2) There was no significantly different of patients age,educational attainments,family income,high blood pressure family history,abdomen circumference,antepartum body mass index, LDL- C,TG,FBG. the serum level sFlt- 1 of severe and mild pre- eclampsia group were significantly higher than the gestational hypertention group. And the serum level sFlt- 1 of severe pre- eclampsia group were significantly higher than the mild pre- eclampsia group (3) Multiple logistic regression analysis showed that sFlt- 1、TG、FBGwere higher risk factors associated with the HDCP, the odds ratio were 1.058、8.619、1.479 respectively. Conclusion(1)The elevated level of serum sFlt- 1 might increase the risk of HDCP. (2)The risk factors of cardiovascular disease were concentrated in HDCP.