现代妇女（医学前沿）
現代婦女（醫學前沿）
현대부녀（의학전연）
Modern Women（Frontiers of Medicine）
2014年
11期
9-11
,共3页
自发性高血压大鼠%血尿酸%左室肥厚%阿托伐他汀
自髮性高血壓大鼠%血尿痠%左室肥厚%阿託伐他汀
자발성고혈압대서%혈뇨산%좌실비후%아탁벌타정
Spontaneously hypertensive rats%Serum uric acid%Left ventricular hypertrophy%Atorvastatin
目的：探讨自发性高血压大鼠（spontaneously hypertensive rats，SHR）血尿酸水平和左室肥厚的相关关系及阿托伐他汀的干预作用。方法将16只8周龄雄性SHR随机分为阿托伐他汀干预组(ATV组, n=8)与SHR模型对照组（SHR组, n=8）；以8只同周龄雄性Wis-tar- Kyoto大鼠作为正常对照（WKY组, n=8）。ATV组用阿托伐他汀(50mg·kg-1·d-1)灌胃，SHR组与WKY组采用等容量蒸馏水灌胃。每隔2周测一次血压。灌胃10周后，测定左室质量指数；观察大鼠血压、血脂、血尿酸的改变。结果干预10周后，ATV组及SHR组血脂、血压无明显差异(P>0.05)。SHR组血尿酸水平及左室肥厚指数明显高于WKY组(P<0.01)；阿托伐他汀干预后，ATV组血尿酸水平及左室重量指数低于SHR组(P<0.05)，与WKY组比较，差异有统计学意义(P<0.05)。血尿酸水平及左室重量指数呈正相关。结论SHR血尿酸水平与左室肥厚密切相关，阿托伐他汀可有效改善左室肥厚。
目的：探討自髮性高血壓大鼠（spontaneously hypertensive rats，SHR）血尿痠水平和左室肥厚的相關關繫及阿託伐他汀的榦預作用。方法將16隻8週齡雄性SHR隨機分為阿託伐他汀榦預組(ATV組, n=8)與SHR模型對照組（SHR組, n=8）；以8隻同週齡雄性Wis-tar- Kyoto大鼠作為正常對照（WKY組, n=8）。ATV組用阿託伐他汀(50mg·kg-1·d-1)灌胃，SHR組與WKY組採用等容量蒸餾水灌胃。每隔2週測一次血壓。灌胃10週後，測定左室質量指數；觀察大鼠血壓、血脂、血尿痠的改變。結果榦預10週後，ATV組及SHR組血脂、血壓無明顯差異(P>0.05)。SHR組血尿痠水平及左室肥厚指數明顯高于WKY組(P<0.01)；阿託伐他汀榦預後，ATV組血尿痠水平及左室重量指數低于SHR組(P<0.05)，與WKY組比較，差異有統計學意義(P<0.05)。血尿痠水平及左室重量指數呈正相關。結論SHR血尿痠水平與左室肥厚密切相關，阿託伐他汀可有效改善左室肥厚。
목적：탐토자발성고혈압대서（spontaneously hypertensive rats，SHR）혈뇨산수평화좌실비후적상관관계급아탁벌타정적간예작용。방법장16지8주령웅성SHR수궤분위아탁벌타정간예조(ATV조, n=8)여SHR모형대조조（SHR조, n=8）；이8지동주령웅성Wis-tar- Kyoto대서작위정상대조（WKY조, n=8）。ATV조용아탁벌타정(50mg·kg-1·d-1)관위，SHR조여WKY조채용등용량증류수관위。매격2주측일차혈압。관위10주후，측정좌실질량지수；관찰대서혈압、혈지、혈뇨산적개변。결과간예10주후，ATV조급SHR조혈지、혈압무명현차이(P>0.05)。SHR조혈뇨산수평급좌실비후지수명현고우WKY조(P<0.01)；아탁벌타정간예후，ATV조혈뇨산수평급좌실중량지수저우SHR조(P<0.05)，여WKY조비교，차이유통계학의의(P<0.05)。혈뇨산수평급좌실중량지수정정상관。결론SHR혈뇨산수평여좌실비후밀절상관，아탁벌타정가유효개선좌실비후。
Objective : to discuss the relationship between serum uric acid and left ventricular hypertrophy in spontaneously hypertensive rats and the intervention effect of?atorvastatin. METHODS: 16 eight-week-old male spontaneously hypertensive rats were randomly divided into atorvastatin group (ATV group, n=8) and spontaneously hypertensive rats group (SHR group, n=8). Age–matched Wistar-kyoto rats were served as normaltensive control group (WKY group, n=8). In ATV group, atorvastatin was given at a dose of 50mg/kg perday by gastric gav-age, and in SHR group and WKY group, the same volume of distilled water was given. Measure the blood pressure every two weeks. Ten weeks later, left ventricular mass index was calculated by the ratio of left ventricular weight to body weight. Plasma lipid levels and blood pressure and serum uric acid were measured. RESULTS: There was not much difference of plasma lipid levels and blood pressure between ATV and SHR group ( P>0.05). Compared with WKY group, serum uric acid level and left ventricular mass index increased significantly in SHR group (P<0.01). After intervention of?atorvastatin,compared with SHR group,serum uric acid level and left ventricular mass index de-creased in ATV group ( P<0.05)and still increased compared with WKY group. The association between serum uric acid level and left ven-tricular mass index is positive correlation. CONCLUSION:Serum uric acid levels are closely associated with left ventricular hypertrophy and atorvastatin can effectively improve the left ventricular hypertrophy.
