中国临床医学
中國臨床醫學
중국림상의학
CLINICAL MEDICAL JOURNAL OF CHINA
2014年
6期
654-655
,共2页
慢性阻塞性肺疾病%哮喘%健康人群%呼出气一氧化氮
慢性阻塞性肺疾病%哮喘%健康人群%呼齣氣一氧化氮
만성조새성폐질병%효천%건강인군%호출기일양화담
Chronic obstructive pulmonary disease%Asthma%Healthy population%Fractional exhaled nitric oxide
目的：探讨呼出气一氧化氮（fractional exhaled nitric oxide，FeNO）检测在支气管哮喘（哮喘）和慢性阻塞性肺疾病诊断中的价值。方法：选择慢性阻塞性肺疾病患者、哮喘患者各120例以及120名健康志愿者，均测定 FeNO 值。结果：慢性阻塞性肺疾病患者、哮喘患者、健康志愿者的 FeNO 测定值分别为（25．8±15．6）ppb、（64．1±51．8）ppb、（18．8±7．3）ppb，慢性阻塞性肺疾病患者和哮喘患者的 FeNO 值与健康志愿者比较差异均有统计学意义（P ＜0．05），慢性阻塞性肺疾病患者与哮喘患者比较差异有统计学意义（P ＜0．01）。3组研究对象的年龄、身高、体质量等一般资料比较差异均无统计学意义。FeNO 测定值与年龄、身高、体质量、体质量指数、第1秒用力呼气容积（FEVI）、第1秒用力呼吸容积与用力肺活量之比（FEVI／FVC）均不存在直线相关性（P ＞0．05）。结论：慢性阻塞性肺疾病及哮喘患者 FeNO 值均高于健康志愿者，FeNO 测定值与 FEVI、FEVI／FVC 等均不存在直线相关性，其原因可能是研究采用的样本量偏少。
目的：探討呼齣氣一氧化氮（fractional exhaled nitric oxide，FeNO）檢測在支氣管哮喘（哮喘）和慢性阻塞性肺疾病診斷中的價值。方法：選擇慢性阻塞性肺疾病患者、哮喘患者各120例以及120名健康誌願者，均測定 FeNO 值。結果：慢性阻塞性肺疾病患者、哮喘患者、健康誌願者的 FeNO 測定值分彆為（25．8±15．6）ppb、（64．1±51．8）ppb、（18．8±7．3）ppb，慢性阻塞性肺疾病患者和哮喘患者的 FeNO 值與健康誌願者比較差異均有統計學意義（P ＜0．05），慢性阻塞性肺疾病患者與哮喘患者比較差異有統計學意義（P ＜0．01）。3組研究對象的年齡、身高、體質量等一般資料比較差異均無統計學意義。FeNO 測定值與年齡、身高、體質量、體質量指數、第1秒用力呼氣容積（FEVI）、第1秒用力呼吸容積與用力肺活量之比（FEVI／FVC）均不存在直線相關性（P ＞0．05）。結論：慢性阻塞性肺疾病及哮喘患者 FeNO 值均高于健康誌願者，FeNO 測定值與 FEVI、FEVI／FVC 等均不存在直線相關性，其原因可能是研究採用的樣本量偏少。
목적：탐토호출기일양화담（fractional exhaled nitric oxide，FeNO）검측재지기관효천（효천）화만성조새성폐질병진단중적개치。방법：선택만성조새성폐질병환자、효천환자각120례이급120명건강지원자，균측정 FeNO 치。결과：만성조새성폐질병환자、효천환자、건강지원자적 FeNO 측정치분별위（25．8±15．6）ppb、（64．1±51．8）ppb、（18．8±7．3）ppb，만성조새성폐질병환자화효천환자적 FeNO 치여건강지원자비교차이균유통계학의의（P ＜0．05），만성조새성폐질병환자여효천환자비교차이유통계학의의（P ＜0．01）。3조연구대상적년령、신고、체질량등일반자료비교차이균무통계학의의。FeNO 측정치여년령、신고、체질량、체질량지수、제1초용력호기용적（FEVI）、제1초용력호흡용적여용력폐활량지비（FEVI／FVC）균불존재직선상관성（P ＞0．05）。결론：만성조새성폐질병급효천환자 FeNO 치균고우건강지원자，FeNO 측정치여 FEVI、FEVI／FVC 등균불존재직선상관성，기원인가능시연구채용적양본량편소。
Objective:To explore the value of fractional exhaled nitric oxide(FeNO)in the diagnosis of bronchial asthma and chronic obstructive pulmonary disease(COPD).Methods:A hundred and twenty patients with COPD,120 patients with asthma and 120 healthy volunteers were enrolled in this study.FeNO value was compared among the three groups.Results:FeNO value in patients with COPD,patients with asthma,healthy volunteers were (25.8± 15.6)ppb,(64.1 ±51.8)ppb,(18.8± 7.3)ppb,respectively.There was significant differences between the patients with COPD or asthma and the healthy volunteers (P <0.05),and there was significant difference between the patients with COPD and the patients with asthma(P <0.01). There was no significant difference in age,height,weight,and other general information among the three groups.There was no linear correlation between FeNO value and age,height,weight,body mass index,forced expiratory volume in the first second (FEVI)and FEVI to forced vital capacity(FEVI/FVC).Conclusions:The measured value of FeNO in patients with COPD and asthma are higher than that of healthy volunteers.There is no linear correlation between the measured value of FeNO and other values such as FEVI and FEVI/FVC,etc.The reason may be small sample size in this study.
