CAJ | 학술논문

目的：分析2型糖尿病患者血脂指标与糖尿病肾病的相关性。方法：选择2011年6月—2013年7月收治的2型糖尿病患者240例，其中合并糖尿病肾病的患者100例，无并发症的患者140例。比较2组患者的性别、年龄、糖尿病病程、血压、基线空腹血糖、糖化血红蛋白以及各项血脂指标，采用 Logistic 回归模型分析各因素与糖尿病肾病关联的比值比（odds ratio， OR）及95％可信区间（confidence interval，CI）。结果：2组患者的年龄、病程、收缩压差异均有统计学意义（P ＜0．01）。Logis-tic 回归模型显示，年龄＞70岁（OR＝2．92，95％CI：1．31～6．51）、病程＞10年（OR＝3．33，95％CI：1．79～6．16）、舒张压＞90 mmHg（OR＝2．23，95％CI：1．06～4．69）、低密度脂蛋白＞3．64 mmol／L（OR＝2．85，95％CI：1．16～7．03）为2型糖尿病合并糖尿病肾病的独立危险因素（P ＜0．05）。结论：低密度脂蛋白有可能作为2型糖尿病合并糖尿病肾病的预测指标和防治靶点。
목적：분석2형당뇨병환자혈지지표여당뇨병신병적상관성。방법：선택2011년6월—2013년7월수치적2형당뇨병환자240례，기중합병당뇨병신병적환자100례，무병발증적환자140례。비교2조환자적성별、년령、당뇨병병정、혈압、기선공복혈당、당화혈홍단백이급각항혈지지표，채용 Logistic 회귀모형분석각인소여당뇨병신병관련적비치비（odds ratio， OR）급95％가신구간（confidence interval，CI）。결과：2조환자적년령、병정、수축압차이균유통계학의의（P ＜0．01）。Logis-tic 회귀모형현시，년령＞70세（OR＝2．92，95％CI：1．31～6．51）、병정＞10년（OR＝3．33，95％CI：1．79～6．16）、서장압＞90 mmHg（OR＝2．23，95％CI：1．06～4．69）、저밀도지단백＞3．64 mmol／L（OR＝2．85，95％CI：1．16～7．03）위2형당뇨병합병당뇨병신병적독립위험인소（P ＜0．05）。결론：저밀도지단백유가능작위2형당뇨병합병당뇨병신병적예측지표화방치파점。
Objective:To analyze the correlation between serum lipid levels and diabetic nephropathy in patients with type 2 di-abetic mellitus.Methods:A total of 240 patients with type 2 diabetic mellitus from Jun 2011 to Jul 2013 were enrolled.There were 100 patients with diabetic nephropathy and 140 patients without any complication.Gender,age,duration of diabetes, baseline fasting glucose,glycosylated hemoglobin and serum lipid were compared between the two groups.The odds ratio(OR) and 95% confidence interval(CI)of correlation between these factors and diabetic nephropathy were calculated and analyzed with Logistic regression model.Results:The differences of age,duration of diabetes,systolic pressure between the two groups were statistically significant(P <0.01).Adjusted Logistic regression model showed that age> 70(OR= 2.92,95% CI:1.31-6.51),duration of diabetes>10 years(OR=3.33,95%CI:1.79-6.16),diastolic pressure>90 mmHg(OR=2.23,95%CI:1.06-4.69),and low density lipoprotein>3.64 mmol/L(OR=2.85,95%CI:1.16-7.03)were independent risk factors for type 2 Dia-betic Mellitus complicated by diabetic nephropathy(P <0.01 and 0.05).Conclusions:Low density lipoprotein has the potential to be a predictive,prophylactic and therapeutic target for diabetic nephropathy.