CAJ | 학술논문

目的：评估PET/CT与MR多模式分子影像技术对盆腔肿瘤的诊断价值，并对高b值反映水通道蛋白信息的水分子扩散成像技术临床价值进行研究。方法选择10例临床诊断明确的盆腔肿瘤患者，先进行18F-FDG?PET/CT全身扫描，然后用专用的患者转运床将患者移到MR进行常规序列和多b值扫描。分别在工作站获得18F-FDG?PET/CT融合图与不同b值DWI所对应水分子扩散成像表观扩散系数（ADC）图。分别统计PET/CT、MRI?+?DWI、MRI?+?AQP及PET/CT结合MRI?+?AQP发现肿瘤的数量，用t检验进行统计学分析。结果 b值大于1500?s/mm2时盆腔膀胱、肠道等自由扩散水分子信号消失，盆腔肿瘤可以清晰显示。18F-FDG PET/CT与MRI?+?AQP发现肿瘤数量与临床诊断间差异无统计学意义（t=?1.50,?P=?0.17；t=-1.0,?P=?0.34），而MRI?+?DWI方法发现的病灶数多于临床诊断（t?=?2.45,?P?=?0.04）。18F-FDG?PET/CT结合MRI与AQP?MR结果与临床诊断结果一致。结论18F-FDG?PET/CT结合MR及其高b值图像能够提高对盆腔肿瘤的检出率。这对于肿瘤早期诊断、准确分期和指导个体化治疗具有重要的价值。
목적：평고PET/CT여MR다모식분자영상기술대분강종류적진단개치，병대고b치반영수통도단백신식적수분자확산성상기술림상개치진행연구。방법선택10례림상진단명학적분강종류환자，선진행18F-FDG?PET/CT전신소묘，연후용전용적환자전운상장환자이도MR진행상규서렬화다b치소묘。분별재공작참획득18F-FDG?PET/CT융합도여불동b치DWI소대응수분자확산성상표관확산계수（ADC）도。분별통계PET/CT、MRI?+?DWI、MRI?+?AQP급PET/CT결합MRI?+?AQP발현종류적수량，용t검험진행통계학분석。결과 b치대우1500?s/mm2시분강방광、장도등자유확산수분자신호소실，분강종류가이청석현시。18F-FDG PET/CT여MRI?+?AQP발현종류수량여림상진단간차이무통계학의의（t=?1.50,?P=?0.17；t=-1.0,?P=?0.34），이MRI?+?DWI방법발현적병조수다우림상진단（t?=?2.45,?P?=?0.04）。18F-FDG?PET/CT결합MRI여AQP?MR결과여림상진단결과일치。결론18F-FDG?PET/CT결합MR급기고b치도상능구제고대분강종류적검출솔。저대우종류조기진단、준학분기화지도개체화치료구유중요적개치。
Objective To?evaluate?the?performance?of?PET/CT-MR?multimodality?molecular?imaging?in?pelvic?tumor?diagnosis,?and?to?investigate?thevalue?of?high?b-value?DWI,?which?reflect?the?aquaporin(AQP),?in?clinical?applications.?Methods 10?subjects,?all?with?confirmed?pelvic?tumors,?was?recruited.?18F-FDG?PET/CT?whole?body?scan?and?multi-b?value?DWI?scans?were?performed.?Special?patient?transport?bed?was?used?to?move?the?subjects?between?scans.?Respectively?in?the?workstation?get?of?18F-FDG?PET/CT?integrated?image?and?the?apparent?diffusion?coefficient(ADC)maps?of?different?b?value.?Respectively?count?the?numbers?of?tumor?on?the?images?of?PET/CT,?MRI?+?DWI,?MRI?+?AQP?and?PET/CT?combined?with?MRI?+?AQP.?The?dates?were?analysed?with?t?test.?Results The?bladder,?bowel?and?pelvic?cavity?when?b?is?greater?than?1500?s/mm2?free?diffusion?of?water?molecules?signal?disappears,?pelvic?tumors?can?be?clearly?showed.?The?differences?between?numbers?of?tumor?on?the?PET/CT?and?MRI?+?DWI?with?clinic?diagnosed?were?not?significant(t=?1.50,?P=?0.17;?t=?-1.0,?P?=?0.34).?The?number?on?MRI?+?DWI?was?more?than?clinic?diagnosed(t =?2.45,?P=?0.04).?The?result?of?PET/CT?combined?with?MRI?+?AQP?was?in?accordance?with?clinic?diagnosed.?Conclusion 18F-FDG?PET/CT?in?combination?with?MR?high?b?value?image?can?improve?the?efficiency?of?pelvic?tumor?diagnosis.?This?for?tumor?early?diagnosis,?accurate?staging?and?guide?individualized?treatment?is?of?great?value.