CAJ | 학술논문

目的：研究胸部病灶18F-脱氧葡萄糖正电子发射断层扫描与CT断层扫描融合显像（18F-FDG?PET/CT）的标准摄取值（SUV）与磁共振单、多指数模型水分子扩散加权成像（DWI）水分子表观扩散系数（ADC）之间定量化关系，以揭示胸部病灶糖代谢与水分子扩散和转运关系。方法选择14例患者，临床病理诊断明确。计算并比较胸部病变SUV与单指数模型（b值0,?1000?s/mm2）、多指数模型（小b值：0?~?200?s/mm2、中b值：300?~?1500?s/mm2和高b值：1700?~?4500?s/mm2）的ADC值。结果良恶性病灶的SUV及单、多指数模型ADC值之间差异无统计学意义（P?>?0.05），提示仅根据SUV或ADC不能鉴别病灶的良恶性。14例患者胸部病灶SUV与单指数模型计算的ADC值之间无明显的相关性（r?=?-0.17），而与多指数模型高b值段计算的ADC值之间呈现明显的相关性（r?=?0.56）。结论 SUV与单指数模型计算的ADC值之间无相关性，而与多指数模型高b值段计算的ADC值之间呈现明显的相关性。这主要与病灶组织细胞在18F-FDG摄取增高的同时，病灶组织细胞水通道蛋白表达增高导致水分子在细胞膜的转运速度增高有关。
목적：연구흉부병조18F-탈양포도당정전자발사단층소묘여CT단층소묘융합현상（18F-FDG?PET/CT）적표준섭취치（SUV）여자공진단、다지수모형수분자확산가권성상（DWI）수분자표관확산계수（ADC）지간정양화관계，이게시흉부병조당대사여수분자확산화전운관계。방법선택14례환자，림상병리진단명학。계산병비교흉부병변SUV여단지수모형（b치0,?1000?s/mm2）、다지수모형（소b치：0?~?200?s/mm2、중b치：300?~?1500?s/mm2화고b치：1700?~?4500?s/mm2）적ADC치。결과량악성병조적SUV급단、다지수모형ADC치지간차이무통계학의의（P?>?0.05），제시부근거SUV혹ADC불능감별병조적량악성。14례환자흉부병조SUV여단지수모형계산적ADC치지간무명현적상관성（r?=?-0.17），이여다지수모형고b치단계산적ADC치지간정현명현적상관성（r?=?0.56）。결론 SUV여단지수모형계산적ADC치지간무상관성，이여다지수모형고b치단계산적ADC치지간정현명현적상관성。저주요여병조조직세포재18F-FDG섭취증고적동시，병조조직세포수통도단백표체증고도치수분자재세포막적전운속도증고유관。
ObjectiveTo?investigate?the?quantitative?relationship?between?glucose?metabolism?and?water?molecules?diffusion?and?transport?by?studying?the?standardized?uptake?value(SUV)of?18F-FDG?PET/CT?and?apparent?diffusion?coefficient(ADC)of?diffusion-weighted?imaging(DWI).?Methods A?total?of?14?patients?with?pathological?diagnosis?were?recruited?for?the?study.?For?each?thoracic?lesion,?the?SUV,?ADC?calculated?with?mono-exponentia?model(b?=?0,?1000?s/mm2),?and?ADC?calculated?with?multiple-exponential?model(low?b,?0?~?200?s/mm2,?middle?b,?300?~?1500?s/mm2?and?high?b,?1700?~?4500?s/mm2)were?compared.?Results There?were?no?significant?differences?in?SUV?or?ADC?between?the?benign?and?malignant?lesions.These?results?indicated?that?SUV?or?ADC?alone?cannot?be?used?to?differentiate?lesions.?In?the?14?thoracic?lesions,?No?significant?correlation?was?found?between?SUV?and?the?ADC?calculated?with?mono-exponentia?mode(b?=?0,?1000?s/mm2)(r?=?-0.17).?However,?SUV?was?significantly?correlated?with?ADC?calculated?with?multiple-exponential?model(b,?1700?~?4500?s/mm2)(r?=?0.56).?Conclusion There?was?no?correlation?between?SUV?and?the?ADC?calculated?with?mono-exponentia?model(b?=?0,?1000?s/mm2).?However,?ADC?calculated?with?multiple-exponential?model(b,?1700?~?4500?s/mm2)was?correlated?with?SUV.?The?reason?may?be?that?when?the?uptake?of?18F-FDG?increased,?the?speed?of?water?molecules?transport?in?the?cell?membrane?was?also?increased?due?to?the?expression?of?water?channel?protein.