CAJ | 학술논문

目的：检测HOST2 lncRNA在上皮性卵巢组织的表达水平，并分析其临床意义。方法：利用实时荧光定量PCR方法检测HOST2 lncRNA在上皮性卵巢癌、上皮性交界性瘤和上皮性正常卵巢组织的表达水平，分析HOST2 lncRNA在不同上皮性卵巢组织表达差异的临床意义。结果：HOST2 lncRNA在上皮性卵巢癌组织和上皮性交界性瘤表达量明显高于上皮性正常卵巢组织的表达，差异均有统计学意义（P<0.01）。HOST2 lncRNA在上皮性卵巢癌组织表达量与上皮性交界性瘤表达量比较无明显差异（P>0.05）。HOST2 lncRNA在不同临床分期的上皮性卵巢癌中表达量无明显差异（P>0.05）。结论：在上皮性卵巢癌和交界性卵巢瘤中HOST2 lncRNA均有表达，可作为上皮性卵巢癌早期诊断的一个分子诊断标志物。
목적：검측HOST2 lncRNA재상피성란소조직적표체수평，병분석기림상의의。방법：이용실시형광정량PCR방법검측HOST2 lncRNA재상피성란소암、상피성교계성류화상피성정상란소조직적표체수평，분석HOST2 lncRNA재불동상피성란소조직표체차이적림상의의。결과：HOST2 lncRNA재상피성란소암조직화상피성교계성류표체량명현고우상피성정상란소조직적표체，차이균유통계학의의（P<0.01）。HOST2 lncRNA재상피성란소암조직표체량여상피성교계성류표체량비교무명현차이（P>0.05）。HOST2 lncRNA재불동림상분기적상피성란소암중표체량무명현차이（P>0.05）。결론：재상피성란소암화교계성란소류중HOST2 lncRNA균유표체，가작위상피성란소암조기진단적일개분자진단표지물。
Objective:To detect the expression of HOST2 lncRNA in epithelial ovarian carcinoma, and analyze its clinical significance.Method:The HOST2 expression of epithelial ovarian cancer , epithelial borderline tumor and epithelial ovarian normal tissues were detected by the PCR method. Clinical significance differences in the expression of HOST2 lncRNA in different ovarian tissue was analyzed.Result:Expression of epithelial ovarian cancer tissue and epithelial borderline tumor was obviously higher than expression of epithelial normal ovarian tissues,there was significant statistical difference (P<0.01). HOST2 lncRNA’s expression of epithelial ovarian cancer tissue was no significant difference with the expression of epithelial borderline tumor tissue (P>0.05).HOST2 lncRNA’s expression of different clinical stages of epithelial ovarian tumor was no significant difference(P>0.05).Conclusion:HOST2 lncRNA expression in ovarian cancer and epithelial borderline tumor, maybe a marker for early diagnosis of ovarian cancer.