CAJ | 학술논문

目的：评估一种新型褪黑素受体激动剂Neu-240对MPTP（1-甲基-4-苯基-1，2，3，6-四氢吡啶）诱导帕金森模型小鼠运动功能损伤的潜在保护作用。方法：C57BL/6小鼠每天腹腔注射一次MPTP （30 mg/kg），连续注射5 d，建立PD小鼠模型；Neu-240（0.1或3 mg/kg）腹腔注射开始于MPTP注射的第1天，1次/d，连续17 d。分别在MPTP注射后第14、15及17天进行行为学检测，包括开放场测试、爬杆测试及悬挂测试。结果：在开放场测试与悬挂测试中，Neu-240能够分别显著性改善MPTP诱导的活动距离与运动评分水平的降低；在爬杆测试中，Neu-240对MPTP诱导的转向时间和总时间无显著性影响，仅表现为改善的趋势。结论：新型褪黑素受体激动剂Neu-240能部分改善帕金森模型小鼠运动功能损伤。
목적：평고일충신형퇴흑소수체격동제Neu-240대MPTP（1-갑기-4-분기-1，2，3，6-사경필정）유도파금삼모형소서운동공능손상적잠재보호작용。방법：C57BL/6소서매천복강주사일차MPTP （30 mg/kg），련속주사5 d，건립PD소서모형；Neu-240（0.1혹3 mg/kg）복강주사개시우MPTP주사적제1천，1차/d，련속17 d。분별재MPTP주사후제14、15급17천진행행위학검측，포괄개방장측시、파간측시급현괘측시。결과：재개방장측시여현괘측시중，Neu-240능구분별현저성개선MPTP유도적활동거리여운동평분수평적강저；재파간측시중，Neu-240대MPTP유도적전향시간화총시간무현저성영향，부표현위개선적추세。결론：신형퇴흑소수체격동제Neu-240능부분개선파금삼모형소서운동공능손상。
Objective:To assess the potential protective effects of the novel melatonin agonist Neu-240 in the MPTP mouse model of Parkinson’s disease.Method:Mice received daily injections of saline or MPTP (30 mg/kg) once per day for five consecutive days to induce Parkinsonism. Vehicle or Neu-240 (0.1 or 3 mg/kg) once per day was administered (i.p.) once per day for 17 days, starting on the first day of MPTP injections. Open field test, pole test and traction test were conducted on day 14, 15 and 17 after the first injections of MPTP, respectively.Result:Neu-240 at 3 mg/kg improved behavioral impairment induced by MPTP in the open field test and traction test but not in the pole test. Neu-240 at 0.1 mg/kg was effective only in the open field test.Conclusion:The novel melatonin agonist Neu-240 exerts partial protective effects in the MPTP mouse model of Parkinson’s disease.