中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2015年
3期
10-12
,共3页
颅脑损伤%血清%脑脊液%S100B蛋白
顱腦損傷%血清%腦脊液%S100B蛋白
로뇌손상%혈청%뇌척액%S100B단백
Craniocerebral injury%Serum%Cerebrospinal fluid%S100B protein
目的：通过检测中重型颅脑损伤后脑脊液及血清中S100B蛋白随时间的水平变化，研究血清及脑脊液中S100B蛋白水平变化的相关性。方法：选取对照组人群48例，测定其血清及脑脊液中S100B蛋白水平。选取中重度颅脑损伤患者（GCS 6~12分）96例，分别于伤后的1、3、5、7、14、21 d取血及脑脊液，检测其S100B水平，比较伤后不同时间的S100B蛋白水平的变化。结果：中重型颅脑损伤后患者血清及脑脊液（Cerebrospinal fluid，CSF）中S100B蛋白水平随时间不断变化的，CSF和血清S100B蛋白峰值均发生在伤后第1天和第3天，各时间点CSF和血清S100B蛋白水平均高于健康对照组，差异有统计学意义（P<0.05），且伤后一段时间内CSF和血清S100B蛋白水平存在一定的相关性。结论：伤后早期脑脊液和血清S100B蛋白水平彼此密切相关，但是随着时间的推移这种相关性逐渐减低。
目的：通過檢測中重型顱腦損傷後腦脊液及血清中S100B蛋白隨時間的水平變化，研究血清及腦脊液中S100B蛋白水平變化的相關性。方法：選取對照組人群48例，測定其血清及腦脊液中S100B蛋白水平。選取中重度顱腦損傷患者（GCS 6~12分）96例，分彆于傷後的1、3、5、7、14、21 d取血及腦脊液，檢測其S100B水平，比較傷後不同時間的S100B蛋白水平的變化。結果：中重型顱腦損傷後患者血清及腦脊液（Cerebrospinal fluid，CSF）中S100B蛋白水平隨時間不斷變化的，CSF和血清S100B蛋白峰值均髮生在傷後第1天和第3天，各時間點CSF和血清S100B蛋白水平均高于健康對照組，差異有統計學意義（P<0.05），且傷後一段時間內CSF和血清S100B蛋白水平存在一定的相關性。結論：傷後早期腦脊液和血清S100B蛋白水平彼此密切相關，但是隨著時間的推移這種相關性逐漸減低。
목적：통과검측중중형로뇌손상후뇌척액급혈청중S100B단백수시간적수평변화，연구혈청급뇌척액중S100B단백수평변화적상관성。방법：선취대조조인군48례，측정기혈청급뇌척액중S100B단백수평。선취중중도로뇌손상환자（GCS 6~12분）96례，분별우상후적1、3、5、7、14、21 d취혈급뇌척액，검측기S100B수평，비교상후불동시간적S100B단백수평적변화。결과：중중형로뇌손상후환자혈청급뇌척액（Cerebrospinal fluid，CSF）중S100B단백수평수시간불단변화적，CSF화혈청S100B단백봉치균발생재상후제1천화제3천，각시간점CSF화혈청S100B단백수평균고우건강대조조，차이유통계학의의（P<0.05），차상후일단시간내CSF화혈청S100B단백수평존재일정적상관성。결론：상후조기뇌척액화혈청S100B단백수평피차밀절상관，단시수착시간적추이저충상관성축점감저。
Objective:To detect the S100B protein change levels in cerebrospinal fluid(Cerebrospinal fluid, CSF) and serum after moderate and severe craniocerebral injury to study the time correlation of levels in cerebrospinal fluid and serum.Method:48 cases were selected as the control group, the levels of S100B protein in serum and cerebrospinal fluid were determined. 96 patients with moderate and severe craniocerebral injury (GCS 6-12 scores) were selected, their serum and cerebrospinal fluid were collected and the concentration of S100B protein,1,3,5,7,14,21 d respectively after injury were detected.Result:After moderate and severe craniocerebral injury,the levels of S100B protein in the serum and Cerebrospinal fluid of patients changed with time. The peaks of S100B protein in CSF and serum were both occurrrd at the first day and the third day after injury, CSF and serum S100B protein levels were higher than control group , the difference was statistically significant(P<0.05) at each time points, the S100B protein levels in CSF and serum existed a certain correlation after a period time of injury.Conclusion:The levels of S100B protein in cerebrospinal fluid and serum are closely related with each other, but this correlation gradually reduced as the time gone by.
