CAJ | 학술논문

目的：了解近2年某儿童医院主要病原菌分布情况及对常用抗菌药物耐药性变迁，为儿科临床合理选择抗菌药物提供依据。方法：收集2012-2013年本院细菌实验室相关数据，统计主要病原菌的检出率、耐药率，对耐药率明显变化的病原菌进行字2检验。结果：近2年儿童医院检出主要病原菌均以革兰染色阴性杆菌为主，革兰染色阴性杆菌对各类抗菌药物耐药率均有不同程度升高；而铜绿假单胞菌对大部分抗菌药物耐药率升高明显（P<0.05）。结论：近2年儿童医院院内感染菌的分布和耐药率有一定变化，特别是铜绿假单胞菌耐药率有升高趋势，提示儿童医院院内感染菌非发酵菌及其耐药率有上升趋势，应加强控感管理，合理使用抗菌药物。
목적：료해근2년모인동의원주요병원균분포정황급대상용항균약물내약성변천，위인과림상합리선택항균약물제공의거。방법：수집2012-2013년본원세균실험실상관수거，통계주요병원균적검출솔、내약솔，대내약솔명현변화적병원균진행자2검험。결과：근2년인동의원검출주요병원균균이혁란염색음성간균위주，혁란염색음성간균대각류항균약물내약솔균유불동정도승고；이동록가단포균대대부분항균약물내약솔승고명현（P<0.05）。결론：근2년인동의원원내감염균적분포화내약솔유일정변화，특별시동록가단포균내약솔유승고추세，제시인동의원원내감염균비발효균급기내약솔유상승추세，응가강공감관리，합리사용항균약물。
Objective:To realize the distribution and drug tolerance change of the main pathogenic bacteria in children’s hospital of the two years, and provide a basis to logical choice of the antibacterial for clinic.Method:The data of bacteriological lab from 2012 to 2013 were collected and the detection rate, tolerance rate of the pathogenic bacteria were summed. And made a chi-square test to the bacteria whose tolerance rate varying obviously.Result:The main pathogenic bacteria in children’s hospital were gram negative bacteria of the last two years. The tolerance to antibacterial of the gram negative bacillus was increased. The tolerance of pseudomonas aeruginosa was increased visibly (P<0.05). Conclusion:There are some changes of pathogenic bacteria’s distribution and drug resistance in children’s hospital for last two years. The drug resistance of pseudomonas aeruginosa is increased. That means non-fermentative bacterial and tolerance in children’s hospital are upward. We shall reinforce managing controlling infection and intelligent using antibacterial.