CAJ | 학술논문

目的：总结血清铁蛋白在老年急性冠状动脉综合征诊断中的价值，探讨血清铁蛋白与老年急性冠状动脉综合征的相关性。方法选取河北省沧州市人民医院2011年1月至2014年1月期间住院治疗的老年急性冠状动脉综合征患者100例，选取同期来本院健康查体者100例为对照，采用Gensini评分系统衡量冠状动脉造影结果，按照Gensini评分结果将观察组分为轻、中、重度组，应用方差分析比较血清铁蛋白在四组中的分布情况，应用多因素回归分析研究Gensini评分与血清铁蛋白的关系。结果观察组患者血清铁蛋白含量（365.44±15.21）ng/mL，显著高于对照组（169.38±12.47）ng/mL，有统计学差异（t=18.64，P<0.05）；重度组血清铁蛋白含量（453.68±21.45）ng/mL，显著高于对照组（169.38±12.47）ng/mL，有统计学差异（t=14.78，P<0.05）；中度组血清铁蛋白含量（289.21±19.35）ng/mL，显著高于对照组（169.38±12.47）ng/mL，有统计学差异（t=11.98，P<0.05）；轻度组血清铁蛋白含量（170.53±13.86）ng/mL，与对照组无显著性差异（t=1.74， P>0.05）。以Gensini评分为应变量，以血清铁蛋白为自变量，进行多元逐步线性回归分析显示，血清铁蛋白与冠状动脉狭窄程度的评分独立相关（回归系数=0.166，标准误=0.077，标准化系数=0.182，t=2.166，P=0.032）。结论老年急性冠状动脉综合征患者的血清铁蛋白含量显著增高，并且与其冠状动脉病变严重程度具有一定相关性，随着病情严重程度的增高，血清铁蛋白的含量随之增高，在老年急性冠状动脉综合征的诊断中提供一定的参考价值。
목적：총결혈청철단백재노년급성관상동맥종합정진단중적개치，탐토혈청철단백여노년급성관상동맥종합정적상관성。방법선취하북성창주시인민의원2011년1월지2014년1월기간주원치료적노년급성관상동맥종합정환자100례，선취동기래본원건강사체자100례위대조，채용Gensini평분계통형량관상동맥조영결과，안조Gensini평분결과장관찰조분위경、중、중도조，응용방차분석비교혈청철단백재사조중적분포정황，응용다인소회귀분석연구Gensini평분여혈청철단백적관계。결과관찰조환자혈청철단백함량（365.44±15.21）ng/mL，현저고우대조조（169.38±12.47）ng/mL，유통계학차이（t=18.64，P<0.05）；중도조혈청철단백함량（453.68±21.45）ng/mL，현저고우대조조（169.38±12.47）ng/mL，유통계학차이（t=14.78，P<0.05）；중도조혈청철단백함량（289.21±19.35）ng/mL，현저고우대조조（169.38±12.47）ng/mL，유통계학차이（t=11.98，P<0.05）；경도조혈청철단백함량（170.53±13.86）ng/mL，여대조조무현저성차이（t=1.74， P>0.05）。이Gensini평분위응변량，이혈청철단백위자변량，진행다원축보선성회귀분석현시，혈청철단백여관상동맥협착정도적평분독립상관（회귀계수=0.166，표준오=0.077，표준화계수=0.182，t=2.166，P=0.032）。결론노년급성관상동맥종합정환자적혈청철단백함량현저증고，병차여기관상동맥병변엄중정도구유일정상관성，수착병정엄중정도적증고，혈청철단백적함량수지증고，재노년급성관상동맥종합정적진단중제공일정적삼고개치。
Objective To summarize the serum ferritin syndrome diagnosis in elderly patients with acute coronary artery, to explore the correlation between serum ferritin in elderly patients with acute coronary syndrome.Methods In the Hebei province Cangzhou people's hospital from January 2011 to January 2014 hospitalized elderly acute coronary syndrome 100 cases of syndrome patients were selected to the hospital in 100 healthy persons as control group. The Gensini scoring system to measure the results of coronary angiography, according to the Gensini score results will be divided into light, in the observation group, severe group, application of analysis of variance comparing distribution of serum ferritin in four groups, multiple factor regression analysis on Gensini score and serum ferritin relationship.Results Serum ferritin levels of (365.44±15.21)ng/mL, signiifcantly higher than the control group of (169.38±12.47)ng/mL, there were signiifcant differences (t=18.64,P<0.05); 3-vessel group serum ferritin in (453.68±21.45)ng/mL, signiifcantly higher than the control group of (169.38±12.47)ng/mL, there was statistical difference (t=14.78,P<0.05); 2 lesion group serum ferritin in (289.21±19.35)ng/mL, signiifcantly higher than the control group of (169.38±12.47)ng/mL, there were signiifcant differences (t=11.98,P<0.05); 1-vessel group serum ferritin in (170.53±13.86)ng/mL, and the control group had no signiifcant difference (t=1.74,P>0.05). The Gensini score as the dependent variable, with serum ferritin as independent variables, multiple stepwise linear regression analysis showed that the degree of correlation, independent of serum ferritin and coronary artery stenosis score (regression coefifcient=0.166, standard error =0.077, standardized coefifcient=0.182,t=2.166,P=0.032).Conclusion The elderly acute coronary syndrome patients serum iron protein content signiifcantly, and has a certain correlation with the severity of coronary artery disease, with the increased severity of illness, the content of serum ferritin increased, the concentration of serum ferritin may be a reference indicator lesions for patients with acute coronary syndrome as the old year, provide certain reference value in the diagnosis of acute coronary syndrome in the elderly.