中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2015年
3期
41-43
,共3页
川崎病%支原体感染%冠脉损伤%相关性
川崎病%支原體感染%冠脈損傷%相關性
천기병%지원체감염%관맥손상%상관성
Kawasaki disease%Mycoplasma infection%Coronary artery lesions%Correlation
目的:研究川崎病(Kawasaki disease,KD)与支原体感染(Mycoplasma pneumomiae,MP)的相关性。方法回顾性分析2012年3月~2014年2月于我院被确诊为KD的84例患儿的病历资料,其中按照患者是否有支原体感染分为观察组和对照组。观察组KD患者为有支原体感染(43例),对照组KD患者无MP感染(41例)。对两组患者分别进行血白细胞计数(WBC)、超敏C反应蛋白(CRP)、红细胞沉降率(ESR)、血红蛋白(HB)以及血小板计数(PLT)的检测和分析。对两组患者是否存在冠脉损伤进行分析比较。结果观察组无冠脉损伤者占34.9%(15/43),明显低于对照组的58.5%(24/41),观察组冠脉损伤者占比65.1%(28/43),显著高于对照组的41.5%(17/41),差异均有统计学意义(P<0.05);观察组的CRP指标水平为(68.9±14.7)mg/L,明显高于对照组的(52.8±8.2)mg/L,观察组的ESR指标水平为(42.6±15.9)mm/h,显著高于对照组的(21.6±6.1)mm/h,差异均有统计学意义(P<0.05)。结论 MP感染为KD的病因之一,MP感染与患者冠脉损伤呈正相关,MP感染引起的免疫介导损伤和炎症反应是发生KD的重要途径。
目的:研究川崎病(Kawasaki disease,KD)與支原體感染(Mycoplasma pneumomiae,MP)的相關性。方法迴顧性分析2012年3月~2014年2月于我院被確診為KD的84例患兒的病歷資料,其中按照患者是否有支原體感染分為觀察組和對照組。觀察組KD患者為有支原體感染(43例),對照組KD患者無MP感染(41例)。對兩組患者分彆進行血白細胞計數(WBC)、超敏C反應蛋白(CRP)、紅細胞沉降率(ESR)、血紅蛋白(HB)以及血小闆計數(PLT)的檢測和分析。對兩組患者是否存在冠脈損傷進行分析比較。結果觀察組無冠脈損傷者佔34.9%(15/43),明顯低于對照組的58.5%(24/41),觀察組冠脈損傷者佔比65.1%(28/43),顯著高于對照組的41.5%(17/41),差異均有統計學意義(P<0.05);觀察組的CRP指標水平為(68.9±14.7)mg/L,明顯高于對照組的(52.8±8.2)mg/L,觀察組的ESR指標水平為(42.6±15.9)mm/h,顯著高于對照組的(21.6±6.1)mm/h,差異均有統計學意義(P<0.05)。結論 MP感染為KD的病因之一,MP感染與患者冠脈損傷呈正相關,MP感染引起的免疫介導損傷和炎癥反應是髮生KD的重要途徑。
목적:연구천기병(Kawasaki disease,KD)여지원체감염(Mycoplasma pneumomiae,MP)적상관성。방법회고성분석2012년3월~2014년2월우아원피학진위KD적84례환인적병력자료,기중안조환자시부유지원체감염분위관찰조화대조조。관찰조KD환자위유지원체감염(43례),대조조KD환자무MP감염(41례)。대량조환자분별진행혈백세포계수(WBC)、초민C반응단백(CRP)、홍세포침강솔(ESR)、혈홍단백(HB)이급혈소판계수(PLT)적검측화분석。대량조환자시부존재관맥손상진행분석비교。결과관찰조무관맥손상자점34.9%(15/43),명현저우대조조적58.5%(24/41),관찰조관맥손상자점비65.1%(28/43),현저고우대조조적41.5%(17/41),차이균유통계학의의(P<0.05);관찰조적CRP지표수평위(68.9±14.7)mg/L,명현고우대조조적(52.8±8.2)mg/L,관찰조적ESR지표수평위(42.6±15.9)mm/h,현저고우대조조적(21.6±6.1)mm/h,차이균유통계학의의(P<0.05)。결론 MP감염위KD적병인지일,MP감염여환자관맥손상정정상관,MP감염인기적면역개도손상화염증반응시발생KD적중요도경。
Objective To invetigate the correlation between Kawasaki disease (KD) and mycoplasma pneumomiae (MP). Methods The medical records of 84 children diagnosed as KD in our hospital from March 2012 to February 2014 were retrospectively analyzed, and according to whether with mycoplasma infection or not ,they were divided into observation group and control group. The observation group included 43 cases with mycoplasma infection, and the control group in-cluded 41 KD patients without MP infection. White blood cell count (WBC), high sensitive C reactive protein (CRP), erythrocyte sedimentation rate (ESR), hemoglobin (HB), platelet count (PLT) were detected and analyzed in two groups. Patients of the two groups were compared in whether the existence of coronary artery lesions. Results Patients of the observation group without coronary artery injury accounted for 34.9%(15/43), significantly lower than that of the con trol group 58.5%(24/41), and the observation group with coronary lesions accounted for 65.1%(28/43), significantly higher than that of the control group 41.5%(17/41). The differences were statistically significant (P<0.05); CRP of the observation group was (68.9±14.7) mg/L, significantly higher than that of the control group (52.8±8.2) mg/L, and ESR of the observation group was (42.6 ±15.9) mm/h, significantly higher than that of the control group (21.6 ±6.1) mm/h. The differences were statistically significant (P<0.05). Conclusion MP is one of the causes of KD and has positive corre-lation with coronary artery injury of patients. The injury and inflammation reaction mediated by autoimmune reaction caused by MP is an important way to KD.