CAJ | 학술논문

目的：探讨冠心病猝死Tp-e间期延长的检测与临床意义。方法选取冠心病患者502例，其中冠心病猝死46例，设为猝死组，其余456例患者设为存活组。比较两组患者Tp-e、Tp-e/√RR 、按心率校正的QT间期（QTc）、左室射血分数（LVEF）的差异，并判断Tp-e间期延长对冠心病猝死的临床意义。结果与存活组比较，猝死组患者Tp-e、Tp-e/√RR 和QTc明显延长（P＜0.05）；与存活组比较，猝死组患者LVEF明显降低（P＜0.05）；Tp-e延长与冠心病猝死、QTc呈正相关（P＜0.05）。结论冠心病猝死患者Tp-e间期明显延长，Tp-e间期延长可能成为冠心病猝死的危险预测指标。
목적：탐토관심병졸사Tp-e간기연장적검측여림상의의。방법선취관심병환자502례，기중관심병졸사46례，설위졸사조，기여456례환자설위존활조。비교량조환자Tp-e、Tp-e/√RR 、안심솔교정적QT간기（QTc）、좌실사혈분수（LVEF）적차이，병판단Tp-e간기연장대관심병졸사적림상의의。결과여존활조비교，졸사조환자Tp-e、Tp-e/√RR 화QTc명현연장（P＜0.05）；여존활조비교，졸사조환자LVEF명현강저（P＜0.05）；Tp-e연장여관심병졸사、QTc정정상관（P＜0.05）。결론관심병졸사환자Tp-e간기명현연장，Tp-e간기연장가능성위관심병졸사적위험예측지표。
Objective To investigate the detection and clinical significance of Tp-e interval extension of sudden coro-nary death. Methods A total of 502 patients with coronary heart disease were selected, of which 46 patients with sud-den coronary death were assigned to the sudden death group and the other 456 patients were assigned to the survival group. The Tp-e, Tp-e/√RR , heart rate-corrected QT inverval (QTc) and left ventricular ejection fraction of the two groups were compared and the clinical significance of Tp-e interval extension for sudden coronary death was decided. Results Compared to the survival group, the sudden death group had significantly extended Tp-e, Tp-e/√RR and QTc(P<0.05);Compared to the survival group, the sudden death group had significantly reduced LVEF (P<0.05); Tp-e extension was positively correlated to sudden coronary death and QTc(P<0.05). Conclusion The Tp-e interval extended obviously in the patients with sudden coronary death and thus can serve as a predictive risk factor of sudden coronary death.