CAJ | 학술논문

目的：探讨初诊2型糖尿病患者血清betatrophin水平及其与胰岛素抵抗水平的关系。方法选择31例健康体检者作为对照组，初诊未经治疗的2型糖尿病患者35例作为初诊T2DM组，采用ELISA法测定betatrophin含量，应用稳态模型评估法计算胰岛素抵抗指数（HOMA-IR）。结果 B组betatrophin、游离脂肪酸、HOMA-IR、空腹血糖、空腹胰岛素、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇高于A组（P<0.05）。结论胰岛素抵抗导致初诊2型糖尿病患者血清betatrophin水平升高。
목적：탐토초진2형당뇨병환자혈청betatrophin수평급기여이도소저항수평적관계。방법선택31례건강체검자작위대조조，초진미경치료적2형당뇨병환자35례작위초진T2DM조，채용ELISA법측정betatrophin함량，응용은태모형평고법계산이도소저항지수（HOMA-IR）。결과 B조betatrophin、유리지방산、HOMA-IR、공복혈당、공복이도소、고밀도지단백담고순、저밀도지단백담고순고우A조（P<0.05）。결론이도소저항도치초진2형당뇨병환자혈청betatrophin수평승고。
Objective To investigate the association between serum betatrophin levels and insulin resistance in newly diagnosed type 2 diabetes patients. Methods A total of 31 healthy subjects (control group) and 35 newly-diagnosed type 2 diabetes patients(new T2DM group) were recruited. Serum betatrophin was detected with the methods of ELISA, insulin resistance was assessed with homeostasis model(HOMA-IR). Results The levels of betatrophin, free fatty acids, HOMA-IR, fasting plasma glucose, fasting serum insulin, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol were significantly higher in group B than those in group A (P<0.05). Conclusion Insulin resis-tance leads to elevated serum levels of betatrophin in patients with newly diagnosed type 2 diabetes.