中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2015年
3期
107-110
,共4页
慢性心力衰竭%硝普钠%氢氯噻嗪
慢性心力衰竭%硝普鈉%氫氯噻嗪
만성심력쇠갈%초보납%경록새진
Chronic heart failure%Sodium nitroprusside%Hydrochlorothiazide
目的：探讨硝普钠联合氢氯噻嗪治疗慢性心力衰竭的临床效果。方法选取2012年8月～2013年10月被确诊为慢性心力衰竭的患者100例，随机分为实验组和对照组各50例，对照组给予常规治疗（β受体阻滞剂、血管紧张素转化酶抑制剂、营养心肌和洋地黄等药物），实验组在常规治疗的基础上加用硝普钠、氢氯噻嗪，通过超声心动图检测两组患者治疗前后左室射血分数（LVEF）和左室舒张末内径（LVDD），实验室检测患者心肌肌钙蛋白（cTnT）、高C-反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）含量，采用纽约心脏协会制定的心功能评定标准，对两组患者的疗效进行判定。结果相较于对照组，治疗后实验组患者的血压、心功能LVEF、LVDD、CRP、cTnT及TNF-α得到改善，6 min步行试验距离更长，总有效率和显效率得到提高，差异具有统计学意义（P＜0.05）。结论硝普钠联合氢氯噻嗪治疗慢性心力衰竭疗效显著，值得临床推广。
目的：探討硝普鈉聯閤氫氯噻嗪治療慢性心力衰竭的臨床效果。方法選取2012年8月～2013年10月被確診為慢性心力衰竭的患者100例，隨機分為實驗組和對照組各50例，對照組給予常規治療（β受體阻滯劑、血管緊張素轉化酶抑製劑、營養心肌和洋地黃等藥物），實驗組在常規治療的基礎上加用硝普鈉、氫氯噻嗪，通過超聲心動圖檢測兩組患者治療前後左室射血分數（LVEF）和左室舒張末內徑（LVDD），實驗室檢測患者心肌肌鈣蛋白（cTnT）、高C-反應蛋白（CRP）、腫瘤壞死因子-α（TNF-α）含量，採用紐約心髒協會製定的心功能評定標準，對兩組患者的療效進行判定。結果相較于對照組，治療後實驗組患者的血壓、心功能LVEF、LVDD、CRP、cTnT及TNF-α得到改善，6 min步行試驗距離更長，總有效率和顯效率得到提高，差異具有統計學意義（P＜0.05）。結論硝普鈉聯閤氫氯噻嗪治療慢性心力衰竭療效顯著，值得臨床推廣。
목적：탐토초보납연합경록새진치료만성심력쇠갈적림상효과。방법선취2012년8월～2013년10월피학진위만성심력쇠갈적환자100례，수궤분위실험조화대조조각50례，대조조급여상규치료（β수체조체제、혈관긴장소전화매억제제、영양심기화양지황등약물），실험조재상규치료적기출상가용초보납、경록새진，통과초성심동도검측량조환자치료전후좌실사혈분수（LVEF）화좌실서장말내경（LVDD），실험실검측환자심기기개단백（cTnT）、고C-반응단백（CRP）、종류배사인자-α（TNF-α）함량，채용뉴약심장협회제정적심공능평정표준，대량조환자적료효진행판정。결과상교우대조조，치료후실험조환자적혈압、심공능LVEF、LVDD、CRP、cTnT급TNF-α득도개선，6 min보행시험거리경장，총유효솔화현효솔득도제고，차이구유통계학의의（P＜0.05）。결론초보납연합경록새진치료만성심력쇠갈료효현저，치득림상추엄。
Objective To investigate the effect of sodium nitroprusside combined with hydrochlorothiazide in the treat-ment of chronic heart failure. Methods The 100 cases of patients with chronic heart failure were selected from August 2012 to October 2013, and they were randomly divided into experimental group (50 cases) and control group (50 cases), control group was given conventional treatment (beta blockers, angiotensin converting enzyme inhibitors, myocardial nutrition and digitalis drugs), the treatment on the basis of conventional combined with sodium nitroprusside, hy-drochlorothiazide was applied in experimental group, by echocardiography through two experimental groups and control group before and after treatment in patients with left ventricular ejection fraction (LVEF) and left ventricular end-dias-tolic diameter (LVDD), laboratory testing in patients with myocardial troponin (cTnT), high C-reactive protein (CRP), tumor necrosis factor alpha (TNF alpha) content, USES the heart function evaluation standards promulgated by the New York heart association, the curative effect of patients in two groups was judged. Results Compared with the patients in control group after treatment, blood pressure, heart function LVEF, LVDD, CRP, cTnT and TNF alpha of experimental group improved, 6 minutes walk test distance was longer, the total effective rate, the efficiency was improved, statistical significance was founded between two groups (P<0.05). Conclusion The effect of sodium nitroprusside combined with hy-drochlorothiazide on patients with chronic heart failure curative is distinct, worth clinical promotion.
