CAJ | 학술논문

目的：肿瘤深部热疗联合羟考酮缓释片治疗骨转移癌痛临床效果以及安全性研究。方法将在我院确诊的120例骨转移癌患者随机分为实验组和对照组，实验组给予肿瘤深部热疗联合羟考酮缓释片治疗，对照组给予羟考酮缓释片口服治疗。观察每天吗啡缓释片用药剂量情况、骨转移癌痛每天爆发痛次数、每天生活质量评分（Karnofsky 评分）、疼痛缓解率以及不良反应状况。结果实验组患者治疗后Karnofsky 行为状况评分为（60.72±6.08）分，而对照组为（30.37±5.31）分，明显低于实验组，差异具有统计学意义（P<0.05）；治疗前两组每天骨转移癌痛爆发痛次数大致相当。随着病情进展，治疗第7天与治疗前比较，骨转移癌痛爆发痛次数实验组没有变化，对照组增加，两组比较差异有显著性（P＜0.05）；第14天两组骨转移癌痛爆发痛次数均增加，但实验组爆发痛增加次数较对照组少，差异有显著性（P＜0.05）；实验组患者经治疗后的总有效率65.08%明显大于对照组（19.30%）（P<0.05）。两组患者的不良反应无明显差异（P>0.05）。结论肿瘤深部热疗联合羟考酮缓释片治疗骨转移癌痛的临床疗效显著，有效改善患者的生活质量，其过程中副作用小，值得在临床推广。
목적：종류심부열료연합간고동완석편치료골전이암통림상효과이급안전성연구。방법장재아원학진적120례골전이암환자수궤분위실험조화대조조，실험조급여종류심부열료연합간고동완석편치료，대조조급여간고동완석편구복치료。관찰매천마배완석편용약제량정황、골전이암통매천폭발통차수、매천생활질량평분（Karnofsky 평분）、동통완해솔이급불량반응상황。결과실험조환자치료후Karnofsky 행위상황평분위（60.72±6.08）분，이대조조위（30.37±5.31）분，명현저우실험조，차이구유통계학의의（P<0.05）；치료전량조매천골전이암통폭발통차수대치상당。수착병정진전，치료제7천여치료전비교，골전이암통폭발통차수실험조몰유변화，대조조증가，량조비교차이유현저성（P＜0.05）；제14천량조골전이암통폭발통차수균증가，단실험조폭발통증가차수교대조조소，차이유현저성（P＜0.05）；실험조환자경치료후적총유효솔65.08%명현대우대조조（19.30%）（P<0.05）。량조환자적불량반응무명현차이（P>0.05）。결론종류심부열료연합간고동완석편치료골전이암통적림상료효현저，유효개선환자적생활질량，기과정중부작용소，치득재림상추엄。
Objective To explore the clinical efficacy and security of tumor deep hyperthermia combined with oxy-codone sustained-release tablets in the treatment of bone metastasis of cancer pain. Methods All 120 cases of bone metastasis of cancer patients diagnosed in our hospital were randomly divided into two group. The experimental group received tumor deep hyperthermia combined with oxycodone sustained-release tablets treatment ,and the control group was given oxycodone sustained-release tablets for treatment.And observe Karnofsky behavior score ,pain relief rate and adverse reaction conditions of two groups. Results After treatment,the experiment group’s Karnofsky behavior score was (60.72±6.08),and the control group’s Karnofsky behavior score was (30.37±5.31),which was significantly lower than the experiment group,the difference was statistically significant (P<0.05);the total efficiency of the experimental group of patients after treatment (65.08%) was significantly greater than the control group of patients with total efficiency (19.30%),there was statistically significant difference (P<0.05). The adverse reactions indexing of two groups pa-tients had no significant difference (P>0.05). Conclusion The clinical efficacy of tumor deep hyperthermia combined with sustained-release oxycodone tablets in the treatment of bone metastases of cancer pain is significantly ,which can improve the quality of life of patients, their process of side effects,so it is worth of promotion in clinic.