CAJ | 학술논문

目的：探讨顺铂联合吉西他滨与顺铂联合紫杉醇治疗晚期非小细胞肺癌的疗效。方法选择我院2012年1月~2014年1月我院收治的非小细胞肺癌患者100例，随机分为观察组（吉西他滨+顺铂，GP组）和对照组（紫杉醇+顺铂，TP组），每组50例，两组患者均每21天为一个周期，连用2个周期以上后观察疗效，比较两组的毒副反应。结果观察组治疗后的有效率达42.0%（21/50），高于对照组的有效率40%（20/50），但组间比较差异无统计学意义（P＞0.05）。观察组、对照组的Ⅲ+Ⅳ度白细胞减少率比较，差异存在显著性（8%vs 30%，P<0.05）。观察组、对照组的Ⅲ+Ⅳ度血小板减少率比较，差异存在显著性（22%vs 4%，P<0.05）。观察组和对照组血红蛋白下降、恶心呕吐、脱发、肝功能损害、肾功能损害的发生率比较，差异无统计学意义（P＞0.05）。结论顺铂联合吉西他滨与顺铂联合紫杉醇治疗晚期非小细胞肺癌的疗效相似，毒副作用各异且均可耐受，均为治疗晚期非小细胞肺癌效果较好的治疗方案。
목적：탐토순박연합길서타빈여순박연합자삼순치료만기비소세포폐암적료효。방법선택아원2012년1월~2014년1월아원수치적비소세포폐암환자100례，수궤분위관찰조（길서타빈+순박，GP조）화대조조（자삼순+순박，TP조），매조50례，량조환자균매21천위일개주기，련용2개주기이상후관찰료효，비교량조적독부반응。결과관찰조치료후적유효솔체42.0%（21/50），고우대조조적유효솔40%（20/50），단조간비교차이무통계학의의（P＞0.05）。관찰조、대조조적Ⅲ+Ⅳ도백세포감소솔비교，차이존재현저성（8%vs 30%，P<0.05）。관찰조、대조조적Ⅲ+Ⅳ도혈소판감소솔비교，차이존재현저성（22%vs 4%，P<0.05）。관찰조화대조조혈홍단백하강、악심구토、탈발、간공능손해、신공능손해적발생솔비교，차이무통계학의의（P＞0.05）。결론순박연합길서타빈여순박연합자삼순치료만기비소세포폐암적료효상사，독부작용각이차균가내수，균위치료만기비소세포폐암효과교호적치료방안。
Objective To investigate the curative effect of cisplatin combined with gemcitabine and cisplatin plus pacli-taxel in the treatment of advanced non-small cell lung cancer. Methods All 100 patients with non-small cell lung can-cer in our hospital from January 2012 to January 2014 in our hospital, randomly divided into observation group (gemc-itabine+cisplatin, GP group) and control group (paclitaxel+cisplatin, TP group), each group had 50 cases, two groups of patients every 21 days for a cycle, observed curative effect after 2 cycles, toxic and adverse reaction were compared between the two groups. Results The effective rate of the observation group after treatment was 42.0%(21/50),was higher than that of the control group 40% (20/50), but there was no significant difference (P>0.05). Conclusion Cura-tive effect of cisplatin combined with gemcitabine and cisplatin plus paclitaxel in the treatment of advanced non-small cell lung cancer is similar, the poisonous side effect is different and can be tolerated, for the treatment of advanced non-small cell lung cancer treatment plan better.