动物营养学报
動物營養學報
동물영양학보
ACTA ZOONUTRIMENTA SINICA
2015年
2期
418-425
,共8页
胡红莲%谢天宇%杨淑青%高民%姚焰础
鬍紅蓮%謝天宇%楊淑青%高民%姚燄礎
호홍련%사천우%양숙청%고민%요염출
亚急性瘤胃酸中毒%奶山羊%细胞因子%激素
亞急性瘤胃痠中毒%奶山羊%細胞因子%激素
아급성류위산중독%내산양%세포인자%격소
SARA%dairy goat%cytokine%hormone
本试验旨在研究以递增饲粮非纤维性碳水化合物与中性洗涤纤维比( NFC/NDF)方式诱导奶山羊发生亚急性瘤胃酸中毒( SARA)后,血浆细胞因子和激素含量的变化。选取9只体况良好,体重接近的泌乳期莎能奶山羊,随机分为3组(对照组、SARA组、恢复组, n=3),对照组饲喂基础饲粮,SARA组和恢复组先后饲喂NFC/NDF为1.40、1.79、2.31、3.23的4种试验饲粮诱导SARA发生,每种饲喂15 d,恢复组奶山羊诱导SARA后自由采食青干草30 d。对照组3只羊分别在饲养30、60(与SARA组同时)和90 d(与恢复组同时)屠宰。结果表明:1) SARA长期提高了血浆LPS浓度,恢复组与SARA组差异不显著( P>0.05)。2)与对照组相比,SARA组奶山羊血浆中促炎性细胞因子肿瘤坏死因子-α( TNF-α)、白细胞介素( IL)-1β和IL-6含量呈升高趋势(P>0.05),IL-2含量显著升高(P<0.05),IL-8含量呈降低趋势(P>0.05),γ-干扰素(IFN-γ)含量显著降低(P<0.05),抗炎性细胞因子IL-4和IL-10含量均呈降低趋势(P>0.05);SARA组奶山羊血浆中生长激素、胰岛素样生长因子-Ⅰ、胰岛素含量变化不显著(P>0.05),催乳素(PRL)和皮质醇(COR)含量均显著升高(P<0.05)。3)与SARA组相比,恢复组奶山羊血浆中TNF-α、IL-1β、IL-2、IL-6这些促炎性细胞因子的含量仍持续性升高,其中IL-1β和IL-2含量显著升高(P<0.05);恢复组奶山羊血浆中PRL含量仍维持与SARA组同一水平(P>0.05),而COR含量则回归到对照组水平( P>0.05)。本研究结果显示,SARA可引起奶山羊血浆中长时间含有一定量的LPS,引发机体免疫和炎症反应,并引起内分泌激素的变化,这一系列变化导致奶山羊长期处于应激状态。
本試驗旨在研究以遞增飼糧非纖維性碳水化閤物與中性洗滌纖維比( NFC/NDF)方式誘導奶山羊髮生亞急性瘤胃痠中毒( SARA)後,血漿細胞因子和激素含量的變化。選取9隻體況良好,體重接近的泌乳期莎能奶山羊,隨機分為3組(對照組、SARA組、恢複組, n=3),對照組飼餵基礎飼糧,SARA組和恢複組先後飼餵NFC/NDF為1.40、1.79、2.31、3.23的4種試驗飼糧誘導SARA髮生,每種飼餵15 d,恢複組奶山羊誘導SARA後自由採食青榦草30 d。對照組3隻羊分彆在飼養30、60(與SARA組同時)和90 d(與恢複組同時)屠宰。結果錶明:1) SARA長期提高瞭血漿LPS濃度,恢複組與SARA組差異不顯著( P>0.05)。2)與對照組相比,SARA組奶山羊血漿中促炎性細胞因子腫瘤壞死因子-α( TNF-α)、白細胞介素( IL)-1β和IL-6含量呈升高趨勢(P>0.05),IL-2含量顯著升高(P<0.05),IL-8含量呈降低趨勢(P>0.05),γ-榦擾素(IFN-γ)含量顯著降低(P<0.05),抗炎性細胞因子IL-4和IL-10含量均呈降低趨勢(P>0.05);SARA組奶山羊血漿中生長激素、胰島素樣生長因子-Ⅰ、胰島素含量變化不顯著(P>0.05),催乳素(PRL)和皮質醇(COR)含量均顯著升高(P<0.05)。3)與SARA組相比,恢複組奶山羊血漿中TNF-α、IL-1β、IL-2、IL-6這些促炎性細胞因子的含量仍持續性升高,其中IL-1β和IL-2含量顯著升高(P<0.05);恢複組奶山羊血漿中PRL含量仍維持與SARA組同一水平(P>0.05),而COR含量則迴歸到對照組水平( P>0.05)。本研究結果顯示,SARA可引起奶山羊血漿中長時間含有一定量的LPS,引髮機體免疫和炎癥反應,併引起內分泌激素的變化,這一繫列變化導緻奶山羊長期處于應激狀態。
본시험지재연구이체증사량비섬유성탄수화합물여중성세조섬유비( NFC/NDF)방식유도내산양발생아급성류위산중독( SARA)후,혈장세포인자화격소함량적변화。선취9지체황량호,체중접근적비유기사능내산양,수궤분위3조(대조조、SARA조、회복조, n=3),대조조사위기출사량,SARA조화회복조선후사위NFC/NDF위1.40、1.79、2.31、3.23적4충시험사량유도SARA발생,매충사위15 d,회복조내산양유도SARA후자유채식청간초30 d。대조조3지양분별재사양30、60(여SARA조동시)화90 d(여회복조동시)도재。결과표명:1) SARA장기제고료혈장LPS농도,회복조여SARA조차이불현저( P>0.05)。2)여대조조상비,SARA조내산양혈장중촉염성세포인자종류배사인자-α( TNF-α)、백세포개소( IL)-1β화IL-6함량정승고추세(P>0.05),IL-2함량현저승고(P<0.05),IL-8함량정강저추세(P>0.05),γ-간우소(IFN-γ)함량현저강저(P<0.05),항염성세포인자IL-4화IL-10함량균정강저추세(P>0.05);SARA조내산양혈장중생장격소、이도소양생장인자-Ⅰ、이도소함량변화불현저(P>0.05),최유소(PRL)화피질순(COR)함량균현저승고(P<0.05)。3)여SARA조상비,회복조내산양혈장중TNF-α、IL-1β、IL-2、IL-6저사촉염성세포인자적함량잉지속성승고,기중IL-1β화IL-2함량현저승고(P<0.05);회복조내산양혈장중PRL함량잉유지여SARA조동일수평(P>0.05),이COR함량칙회귀도대조조수평( P>0.05)。본연구결과현시,SARA가인기내산양혈장중장시간함유일정량적LPS,인발궤체면역화염증반응,병인기내분비격소적변화,저일계렬변화도치내산양장기처우응격상태。
This experiment was conducted to investigate the effects of subacute ruminal acidosis ( SARA) in-duced by gradually increasing dietary non-fiber carbohydrate/neutral detergent fiber ratios ( NFC/NDF ) on plasma hormone and cytokine contents in dairy goats. Nine healthy lactating Saanen dairy goats with similar body weight were randomly allocated to three groups ( control group, SARA group and recovery group, n=3 ) . Dairy goats in control group were fed a basal diet;those in SARA group and recovery group were fed diets with different NFC/NDF (1.40, 1.79, 2.31 and 3.23, respectively, each for 15 days), which gradually in-duced SARA; those in recovery group were ad libitum fed green hay for 30 days after SARA. The three goats in control group were slaughtered on days 30, 60 ( together with SARA goup) and 90 of feeding ( together with recovery group) . The results showed as follows:1) plasma lipopolysaccharide ( LPS) concentration was increased for a long time as a result of SARA challenge, and there was no significant difference between SARA group and recovery group ( P>0.05) . 2) Compared with control group, the contents of plasma tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and IL-6 tended to be increased (P>0.05), and IL-2 content was significantly increased (P<0.05), but interferon-γ (IFN-γ) content was significantly decreased (P<0.05), and the contents of plasma IL-4, IL-8 and IL-10 tended to be decreased in SARA group ( P>0.05); the con-tents of plasma growth hormone, insulin-like growth factor-Ⅰ and insulin were not changed (P>0.05), and the contents of prolactin and cortisol were significantly increased ( P<0.05) . 3) Compared with SARA group, the contents of plasma TNF-α, IL-1β, IL-2, IL-6 in recovery group were still persistently increased, in which IL-1β and IL-2 contents were significantly increased ( P<0.05); plasma prolactin content stayed at the same level as SARA group ( P>0.05) , and plasma cortisol content was back to the same level as control group ( P>0.05). These results indicate that SARA can increase plasma LPS concentration of dairy goats, which can lead to systemic immune and inflammatory responses, endocrine hormones alterations. These changes will result in stress of dairy goats for a long time.