CAJ | 학술논문

炎症是动物机体对病原菌、损伤组织和刺激物等产生的有害刺激做出的一种生理性应答。炎症反应可通过调节多种炎症介质及信号通路最终影响炎症因子的表达。表观遗传学涉及非DNA序列改变引起的可遗传变化，主要包括DNA甲基化、组蛋白修饰和非编码RNA表达调控。表观遗传修饰可通过影响炎症反应中相关基因的表达来调节炎症反应，饲粮中能够影响表观遗传学修饰过程的营养素可调节炎症反应。本文主要综述了营养素调控炎症的表观遗传学机制———DNA甲基化和组蛋白修饰。
염증시동물궤체대병원균、손상조직화자격물등산생적유해자격주출적일충생이성응답。염증반응가통과조절다충염증개질급신호통로최종영향염증인자적표체。표관유전학섭급비DNA서렬개변인기적가유전변화，주요포괄DNA갑기화、조단백수식화비편마RNA표체조공。표관유전수식가통과영향염증반응중상관기인적표체래조절염증반응，사량중능구영향표관유전학수식과정적영양소가조절염증반응。본문주요종술료영양소조공염증적표관유전학궤제———DNA갑기화화조단백수식。
Inflammation is a physiological response of animal body to detrimental stimuli induced by patho-gens, damaged tissue and stimulus. The inflammatory response is orchestrated by inflammatory cytokines, which can be regulated through inflammatory mediators and related signaling pathways. Epigenetics is the study of heritable changes which are not caused by changes in the DNA sequence, including DNA methylation, his-tone modification and non-coding RNAs, etc. Nutrients can regulate inflammatory response, through altering epigenetic modification of the key inflammatory cytokines. This paper reviewed the mechanism of epigenetic modulations of nutrients on inflammation in animals, which were DNA methylation and histone modification.