CAJ | 학술논문

高精低粗的饲粮结构会引起奶牛瘤胃内乳酸和挥发性脂肪酸浓度升高，瘤胃液pH降低，导致瘤胃内微生物区系发生改变，从而引起瘤胃内异常代谢产物(细菌内毒素、组胺等)增加，甚至引发亚急性瘤胃酸中毒。其中，组胺是机体内重要的炎性介质，高浓度的组胺转运至血液后可引起机体炎症反应，引起奶牛多种疾病，并使奶牛生产性能下降。本文对奶牛瘤胃异常发酵时组胺的产生和转运以及组胺诱导炎性反应的机制进行综述，同时，介绍一些限制组胺生成和转运的方法，为控制和减少组胺对奶牛的危害提供参考。
고정저조적사량결구회인기내우류위내유산화휘발성지방산농도승고，류위액pH강저，도치류위내미생물구계발생개변，종이인기류위내이상대사산물(세균내독소、조알등)증가，심지인발아급성류위산중독。기중，조알시궤체내중요적염성개질，고농도적조알전운지혈액후가인기궤체염증반응，인기내우다충질병，병사내우생산성능하강。본문대내우류위이상발효시조알적산생화전운이급조알유도염성반응적궤제진행종술，동시，개소일사한제조알생성화전운적방법，위공제화감소조알대내우적위해제공삼고。
Feeding the high-concentrate and low-roughage diet to dairy cows can increase the concentrations of lactic acid and volatile fatty acids and decrease the ruminal pH, resulting in rumen microflora changes, the re-lease of abnormal metabolic products, such as bacterial endotoxin and histamine, and even cause subacute ru-minal acidosis. Histamine is an important inflammatory mediator. After high concentration of histamine is trans-ported to the blood, it plays an important role in inflammation, causing histamine related diseases, so that the dairy cows’ production performance is decreased. This paper described the histamine formation and transporta-tion in dairy cows and also discussed the possible mechanisms of the histamine-induced inflammatory respon-ses, finally some methods for reducing histamine release in the rumen and its transportation into the body were proposed.