CAJ | 학술논문

线粒体既是细胞内能量转换器，又是决定细胞存活及凋亡的重要因素。线粒体损伤、功能失调与多种神经元退行性变疾病发生发展均密切相关。青光眼为视神经病变的一种，近年来研究发现，线粒体的氧化应激在青光眼的发病及视网膜神经节细胞损害过程中尤其重要。本文对氧化应激-线粒体功能异常与视网膜神经节细胞凋亡关系的最新研究进展作以综述。
선립체기시세포내능량전환기，우시결정세포존활급조망적중요인소。선립체손상、공능실조여다충신경원퇴행성변질병발생발전균밀절상관。청광안위시신경병변적일충，근년래연구발현，선립체적양화응격재청광안적발병급시망막신경절세포손해과정중우기중요。본문대양화응격-선립체공능이상여시망막신경절세포조망관계적최신연구진전작이종술。
Mitochondria play an important role in energy ( ATP ) production through oxidative phosphorylation pathway and the regulation of cell death by apoptosis. Mitochondrial dysfunction has been implicated in the pathophysiology of a number of neurodegenerative diseases. Glaucoma as a neurodegenerative disorder, mitochondrial oxidative stress in the pathogenesis of glaucoma and the damage of RGCs has received close attention in recent years. ln this article, we reviewed the current evidences and recent advances in the relationship between mitochondrial oxidative stress and the RGCs apoptosis.