CAJ | 학술논문

目的：探讨血管内皮生长因子（ VEGF）在小细胞肺癌（ SCLC）肿瘤组织中的表达及对其预后的影响。方法采用polymer免疫组化方法检测64例SCLC患者肿瘤组织中VEGF水平。结果64例SCLC患者中VEGF阳性表达率为43．3％，且所有患者均为弱阳性表达。57例获随访的患者中，VEGF表达阳性与阴性患者的中位生存期比较无统计学差异（14个月vs 21个月，P＝0．539）。结论 VEGF表达与患者的预后无显著相关。
목적：탐토혈관내피생장인자（ VEGF）재소세포폐암（ SCLC）종류조직중적표체급대기예후적영향。방법채용polymer면역조화방법검측64례SCLC환자종류조직중VEGF수평。결과64례SCLC환자중VEGF양성표체솔위43．3％，차소유환자균위약양성표체。57례획수방적환자중，VEGF표체양성여음성환자적중위생존기비교무통계학차이（14개월vs 21개월，P＝0．539）。결론 VEGF표체여환자적예후무현저상관。
Objective To investigate the correlation between the expression of vascular endothelial growth factor ( VEGF) in small cell lung cancer( SCLC) and prognosis.Methods The level of VEGF in tumor tissues of 64 SCLC patients was analyzed by polymer immunohistochemistry.Results The posotive expression rate of VEGF in all SCLC patients was 43.3%and all results were weakly positive.In 57 successful followed-up cases,median survival time( MST) between positive and nega-tive VEGF expression(14 months vs 21 months,P=0.539) had no difference.Conclusion The VEGF expression in SCLC pa-tients has no significant correlation with prognosis.