CAJ | 학술논문

目的探讨血管内皮生长因子-C（VEGF-C）与其受体-3（VEGFR-3）与胃癌临床病理因素的关系。方法采用免疫组织化学染色，检测20例正常胃组织和98例胃癌组织中VEGF-C表达。结果胃癌组织中VEGF-C阳性表达率为71．4％（70／98），而癌旁组织和正常胃粘膜组织中其阳性表达率为9．2％（9／98）和5．0％（1／20）。98例胃癌组织中VEGF-C表达与患者性别、肿瘤直径大小、肿瘤部位、分化程度、是否存在血管浸润以及浸润深度无显著相关，而与淋巴结转移、淋巴管浸润、远处转移、TNM临床分期显著相关（P＜0．05）。结论 VEGF-C及其受体系统是淋巴管生成的重要调节因子，对于胃癌区域淋巴管生成、淋巴转移途径有非常重要的意义。
목적탐토혈관내피생장인자-C（VEGF-C）여기수체-3（VEGFR-3）여위암림상병리인소적관계。방법채용면역조직화학염색，검측20례정상위조직화98례위암조직중VEGF-C표체。결과위암조직중VEGF-C양성표체솔위71．4％（70／98），이암방조직화정상위점막조직중기양성표체솔위9．2％（9／98）화5．0％（1／20）。98례위암조직중VEGF-C표체여환자성별、종류직경대소、종류부위、분화정도、시부존재혈관침윤이급침윤심도무현저상관，이여림파결전이、림파관침윤、원처전이、TNM림상분기현저상관（P＜0．05）。결론 VEGF-C급기수체계통시림파관생성적중요조절인자，대우위암구역림파관생성、림파전이도경유비상중요적의의。
Objective To study the vascular endothelial growth factor-C(VEGF-C) and its receptor(VEGFR-3) and their relationship with clinical pathological factors of gastric cancer.Methods Expression of VEGF-C in 20 cases of normal gas-tric tissues and 98 cases of gastric cancer tissues were detected by immunohistochemical staining.Results VEGF-C positive ex-pression rate was 71.4%(70/98) in gastric cancer tissues,and VEGF-C positive expression rates in tissues adjacent to tumors and normal gastric mucosa tissues were 9.2%(9/98) and 5.0%(1/20).The expression of VEGF-C in 98 cases of gastric cancer tissues and patient's gender,tumor diameter,size,location,degree of differentiation,presence of vascular invasion and infiltration depth had no significant correlation,but were significantly correlated with lymph node metastasis,lymphatic vessel invasion,distant metastasis,and TNM clinical stage (P<0.05).Conclusion VEGF-C and its receptor system is an important regulatory factor of lymphangiogenesis,it has very important significance in lymphangiogenesis of gastric cancer region and lymphatic metastasis.