实用癌症杂志
實用癌癥雜誌
실용암증잡지
THE PRACTICAL JOURNAL OF CANCER
2015年
2期
211-213
,共3页
全身麻醉%硬膜外麻醉%肺癌根治术%免疫功能%自主呼吸
全身痳醉%硬膜外痳醉%肺癌根治術%免疫功能%自主呼吸
전신마취%경막외마취%폐암근치술%면역공능%자주호흡
General anesthesia%Epidural anesthesia%Radical operation of lung cancer%Immune function%Spontaneous breathing
目的：探讨全麻复合硬膜外麻醉对肺癌根治术患者细胞免疫功能的影响。方法将行肺癌根治术的70例患者随机分成观察组和对照组，各35例。对照组：采用全身麻醉。观察组：采用全麻复合硬膜外麻醉。结果观察组恢复自主呼吸时间、轻呼睁眼时间、拔管时间明显优于对照组，差异有统计学意义（P＜0．01）。术后第1天，2组CD3＋、CD4＋、CD8＋、CD4＋／CD8＋、NK 细胞水平明显低于术前，差异有统计学意义（ P＜0．01）；术后第1天，观察组CD3＋、CD4＋、CD8＋、CD4＋／CD8＋、NK细胞水平高于对照组，差异有统计学意义（ P＜0．05）。术后第7天，2组NK细胞水平明显低于术前，差异有统计学意义（ P＜0．01）；术后第7天，观察组NK细胞水平高于对照组，差异有统计学意义（ P＜0．05）。结论全麻联合硬膜外麻醉对于行肺癌根治术患者，具有细胞免疫功能影响较小，术后恢复快等特点。
目的：探討全痳複閤硬膜外痳醉對肺癌根治術患者細胞免疫功能的影響。方法將行肺癌根治術的70例患者隨機分成觀察組和對照組，各35例。對照組：採用全身痳醉。觀察組：採用全痳複閤硬膜外痳醉。結果觀察組恢複自主呼吸時間、輕呼睜眼時間、拔管時間明顯優于對照組，差異有統計學意義（P＜0．01）。術後第1天，2組CD3＋、CD4＋、CD8＋、CD4＋／CD8＋、NK 細胞水平明顯低于術前，差異有統計學意義（ P＜0．01）；術後第1天，觀察組CD3＋、CD4＋、CD8＋、CD4＋／CD8＋、NK細胞水平高于對照組，差異有統計學意義（ P＜0．05）。術後第7天，2組NK細胞水平明顯低于術前，差異有統計學意義（ P＜0．01）；術後第7天，觀察組NK細胞水平高于對照組，差異有統計學意義（ P＜0．05）。結論全痳聯閤硬膜外痳醉對于行肺癌根治術患者，具有細胞免疫功能影響較小，術後恢複快等特點。
목적：탐토전마복합경막외마취대폐암근치술환자세포면역공능적영향。방법장행폐암근치술적70례환자수궤분성관찰조화대조조，각35례。대조조：채용전신마취。관찰조：채용전마복합경막외마취。결과관찰조회복자주호흡시간、경호정안시간、발관시간명현우우대조조，차이유통계학의의（P＜0．01）。술후제1천，2조CD3＋、CD4＋、CD8＋、CD4＋／CD8＋、NK 세포수평명현저우술전，차이유통계학의의（ P＜0．01）；술후제1천，관찰조CD3＋、CD4＋、CD8＋、CD4＋／CD8＋、NK세포수평고우대조조，차이유통계학의의（ P＜0．05）。술후제7천，2조NK세포수평명현저우술전，차이유통계학의의（ P＜0．01）；술후제7천，관찰조NK세포수평고우대조조，차이유통계학의의（ P＜0．05）。결론전마연합경막외마취대우행폐암근치술환자，구유세포면역공능영향교소，술후회복쾌등특점。
Objective To study the effect of general anesthesia combined with epidural anesthesia on cellular immune function in lung cancer patients treated with radical operation.Methods 70 cases of lung cancer treated with radical operation were randomly divided into the observation group and the control group,35 cases in each.The control group received general anes-thesia.The observation group received general anesthesia combined with epidural anesthesia.Results Restoration of spontaneous breathing time,light shout opening time,extubation time in the observation group were better than those of the control group,there were statistically significant differences(P<0.01).1 day after operation,1D,CD3 +,CD4 +,CD8 +,CD4 +/CD8 +,NK cell level of the 2 groups decreased,the difference was statistically significant(P<0.01).1 day after operation,1D,CD3 +,CD4 +,CD8 +, CD4 +/CD8 +,NK cell level of the observation group were higher than that those of the control group,there were statistically sig-nificant differences(P<0.05).7 days after the operation,NK cell level of the 2 groups decreased,the difference was statistically significant(P<0.01).7 days after the operation,NK cells of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion General anesthesia combined with epidural anesthesia for lung cancer patients treated with radical operation,has less effect on cell immune function and quick recovery after operation.
