CAJ | 학술논문

目的：：应用Meta 分析探讨 IGF-1基因2个多态性位点( rs6214和rs12423791)与高度近视易患性的关系。方法：两名作者独立检索 PubMed、EMBASE、中国期刊全文数据库( CNKI)从建库到2014-03-12发表的文献,合并效应采用比值比和95%可信区间进行评价, Meta分析软件运用RevMan5.2和Stata 12.0。结果：五篇病例对照研究进入Meta分析,包括病例组2585例,对照组3327例,各基因模型均显示两个位点基因多态性与高度近视易患性无显著相关性。结论：现有证据表明,尚不能认为 IGF-1两个位点rs6214A/G,rs12324791G/C 基因多态性与高度近视有关联性。
목적：：응용Meta 분석탐토 IGF-1기인2개다태성위점( rs6214화rs12423791)여고도근시역환성적관계。방법：량명작자독립검색 PubMed、EMBASE、중국기간전문수거고( CNKI)종건고도2014-03-12발표적문헌,합병효응채용비치비화95%가신구간진행평개, Meta분석연건운용RevMan5.2화Stata 12.0。결과：오편병례대조연구진입Meta분석,포괄병례조2585례,대조조3327례,각기인모형균현시량개위점기인다태성여고도근시역환성무현저상관성。결론：현유증거표명,상불능인위 IGF-1량개위점rs6214A/G,rs12324791G/C 기인다태성여고도근시유관련성。
AlM: To investigate the association between the single nucleotide polymorphisms (SNP) (rs6214 and rs12423791) in lGF-1 and high myopia susceptibility by performing a Meta-analysis.METHODS: PubMed, EMBASE, and Chinese National Knowledge lnfrastructure ( up to March 12, 2014 ) were searched by two authors independently. Crude odds ratios with 95%Cls were used to assess the strength of the associations between SNP rs6214, rs12324791 and high myopia. Statistical analysis was performed using the program RevMan5. 2 software ( Revman; The Cochrane Collaboration, Oxford, UK ) and STATA 12. 0 software ( Stata Corporation, College Station, TX, USA) .RESULTS:Five case-control studies with involving 2585 patients with high myopia and 3327 controls were included in this Meta - analysis. No statistical evidence of significant association was found in all genetic models of rs6214A/G and rs12324791G/C.CONCLUSlON: This Meta-analysis suggested that the rs6214A/G and rs12324791G/C mutation in the insulin-like growth factor-1 are not significantly associated with high myopia.