CAJ | 학술논문

目的：探讨新辅助化疗（ NACT）治疗宫颈小细胞癌（ SCCC）的临床效果。方法按照患者是否于术前接受NACT，将62例SCCC患者分为实验组（接受NACT）33例和对照组（未接受NACT）29例，记录实验组患者近期疗效，比较两组患者入院时与术前病灶大小变化情况、远期疗效及复发情况。结果实验组患者CR 5例（15．15％），PR 24例（72．73％），SD 4例（12．12％），总有效率为87．88％；实验组患者经NACT后病灶均有不同程度缩小，术前病理检查测量肿瘤病灶最大直径显著小于入院时影像学测量肿瘤病灶最大直径，差异具有统计学意义（P＜0．05）；实验组患者术前病理检查测量肿瘤病灶最大直径显著小于对照组，差异具有统计学意义（P＜0．05）；两组患者3年总生存率、3年无瘤生存率和局部复发率比较，差异无统计学意义（P＞0．05）；实验组患者远处复发率显著低于对照组，差异具有统计学意义（P＜0．05）。结论 SCCC术前经NACT可有效缩小靶病灶，降低远处复发率，临床效果显著，应用价值较高。
목적：탐토신보조화료（ NACT）치료궁경소세포암（ SCCC）적림상효과。방법안조환자시부우술전접수NACT，장62례SCCC환자분위실험조（접수NACT）33례화대조조（미접수NACT）29례，기록실험조환자근기료효，비교량조환자입원시여술전병조대소변화정황、원기료효급복발정황。결과실험조환자CR 5례（15．15％），PR 24례（72．73％），SD 4례（12．12％），총유효솔위87．88％；실험조환자경NACT후병조균유불동정도축소，술전병리검사측량종류병조최대직경현저소우입원시영상학측량종류병조최대직경，차이구유통계학의의（P＜0．05）；실험조환자술전병리검사측량종류병조최대직경현저소우대조조，차이구유통계학의의（P＜0．05）；량조환자3년총생존솔、3년무류생존솔화국부복발솔비교，차이무통계학의의（P＞0．05）；실험조환자원처복발솔현저저우대조조，차이구유통계학의의（P＜0．05）。결론 SCCC술전경NACT가유효축소파병조，강저원처복발솔，림상효과현저，응용개치교고。
Objective To explore the clinical effects of neoadjuvent chemotherapy ( NACT) for small cell carcinoma of cervix(SCCC).Methods 62 cases of SCCC were divided into the experiment group(33 cases,treated by NACT) and the control group(29 cases,not treated by NACT).The short-term effects of the experiment group were record,the tumor size,long-term effect,and relapse were compared between the 2 groups.Results The CR were 5 cases ( 15.15%) , PR were 24 cases (72.73%),SD were 4 cases(12.12%),the total effective rate was 87.88%;The tumor size reduced after NACT ,Preoperative maximum tumor lesion diameter by pathological examination was significantly smaller than maximum tumor lesion diameter by im-aging measurement on admission(P<0.05);Preoperative maximum tumor lesion diameter by pathological examination in the ex-periment group was smaller than that of the control group(P<0.05);There were no significant differences in the 3-year overall survival,3-year disease-free survival and local recurrence between the 2 groups(P>0.05);The distant recurrence rate in the ex-periment group was significantly lower than that of the control group(P<0.05).Conclusion Preoperative NACT for SCCC can effectively reduce the target lesion and distant recurrence rate.It has significant clinical effect and high application value.