CAJ | 학술논문

目的：探讨影响弥漫浸润型（ BormannⅣ型）胃癌患者的独立预后因素。方法回顾性分析83例经手术治疗及病理检查证实为弥漫浸润型胃癌患者的临床病理资料和随访结果，采用Kaplan-Meier法进行生存分析，采用Log-rank检验进行比较。结果 CA199≤40 U／L患者中位生存时间为19个月， CA199＞40 U／L 患者中位生存时间为5个月。全组患者均获得随访，中位生存时间为15个月，1、3、5年总生存率分别为55．4％、21．1％和11．9％。单因素分析显示，手术方式、远处转移、CA199水平、淋巴结转移情况、肿瘤侵犯深度是影响BormannⅣ型胃癌患者预后的重要因素（ P＜0．05），而患者年龄、性别、CEA及CA724水平与预后无关（P＞0．05）。结论手术方式、远处转移、CA199水平、淋巴结转移情况、肿瘤侵犯深度是影响BormannⅣ胃癌患者预后的重要因素。
목적：탐토영향미만침윤형（ BormannⅣ형）위암환자적독립예후인소。방법회고성분석83례경수술치료급병리검사증실위미만침윤형위암환자적림상병리자료화수방결과，채용Kaplan-Meier법진행생존분석，채용Log-rank검험진행비교。결과 CA199≤40 U／L환자중위생존시간위19개월， CA199＞40 U／L 환자중위생존시간위5개월。전조환자균획득수방，중위생존시간위15개월，1、3、5년총생존솔분별위55．4％、21．1％화11．9％。단인소분석현시，수술방식、원처전이、CA199수평、림파결전이정황、종류침범심도시영향BormannⅣ형위암환자예후적중요인소（ P＜0．05），이환자년령、성별、CEA급CA724수평여예후무관（P＞0．05）。결론수술방식、원처전이、CA199수평、림파결전이정황、종류침범심도시영향BormannⅣ위암환자예후적중요인소。
Objective To investigate the independent prognostic factors of survival for diffuse infiltrative-type gastric cancer ( BormannⅣtype) .Methods The clinicopathological and follow-up data of 83 patients with diffuse infiltrative-type gas-tric cancer who were diagnosed by surgical resection and pathology were analyzed retrospectively.The survival was estimated using Kaplan-Meier method and compared by log-rank test.Results Median survival of patients with CA199 ≤40 U/L was 19 months,median survival of patients with CA199>40 U/L was 5 months.All the 83 patients were followed up.The median survival was 15 months,and the overall 1-,3-,5-year survival rates were 55.4%,21.1% and 11.9%,respectively.Univariate analysis showed that surgical approach,distant metastasis,CA199,lymphatic invasion and depth of invasion were prognostic factors of Bor-mannⅣtype gastric cancer(P<0.05),while gender,age,CEA and CA724 were not significantly correlated with prognosis.Con-clusion Surgical approach,distant metastasis,CA199,lymphatic invasion and depth of invasion are prognostic factors of BormannⅣtype gastric cancer.