CAJ | 학술논문

目的：探讨贝伐珠单抗联合多西紫杉醇、5-氟尿嘧啶（5-FU）以及顺铂化疗治疗晚期胃癌的疗效。方法将76例晚期胃癌患者根据随机数字表法随机分为对照组（ n＝38）和观察组（ n＝38）。对照组采用多西紫杉醇、5-FU以及顺铂化疗治疗，观察组在对照组化疗基础上结合贝伐珠单抗治疗。2组患者均以21 d为1个周期，治疗2个周期后评价2组患者近期疗效，生存质量以及不良反应。结果观察组总有效率（63．16％）显著高于对照组（39．47％），且具有统计学差异（P＜0．05）。2组患者治疗前Karmofsky评分比较不具有统计学差异（P＞0．05）；治疗后观察组Karmofsky评分显著高于对照组，且具有统计学差异（P＜0．05）。2组患者不良反应发生率比较不具有统计学差异（P＞0．05）。结论贝伐珠单抗联合多西紫杉醇、5-FU以及顺铂化疗治疗晚期胃癌取得了明显的临床疗效，提高了患者生存质量，且患者可耐受不良反应，具有重要临床研究价值。
목적：탐토패벌주단항연합다서자삼순、5-불뇨밀정（5-FU）이급순박화료치료만기위암적료효。방법장76례만기위암환자근거수궤수자표법수궤분위대조조（ n＝38）화관찰조（ n＝38）。대조조채용다서자삼순、5-FU이급순박화료치료，관찰조재대조조화료기출상결합패벌주단항치료。2조환자균이21 d위1개주기，치료2개주기후평개2조환자근기료효，생존질량이급불량반응。결과관찰조총유효솔（63．16％）현저고우대조조（39．47％），차구유통계학차이（P＜0．05）。2조환자치료전Karmofsky평분비교불구유통계학차이（P＞0．05）；치료후관찰조Karmofsky평분현저고우대조조，차구유통계학차이（P＜0．05）。2조환자불량반응발생솔비교불구유통계학차이（P＞0．05）。결론패벌주단항연합다서자삼순、5-FU이급순박화료치료만기위암취득료명현적림상료효，제고료환자생존질량，차환자가내수불량반응，구유중요림상연구개치。
Objective To study the efficacy of bevacizumab combined with docetaxel,5-fluorouracil and cisplatin chem-otherapy in the treatment of advanced gastric cancer.Methods 76 cases of advanced gastric cancer patients according to the ran-dom number table method were randomly divided into the control group(n=38)and the observation group(n=38).The control group received 5-FU and docetaxel,cisplatin chemotherapy treatment,the observation group received bevacizumab on the base of the control group.21 d was 1 cycles for both groups,the recent curative effect,quality of life scores and adverse reaction of the 2 groups after 2 cycles of therapy were evaluated.Results Total effective rate of the observation group(63.16%)was significantly higher than that of the control group(39.47%) ,and there had statistical difference( P<0.05);Karmofsky scores of the 2 groups before the treatment had no statistical difference( P>0.05);Karmofsky score of the observation group after treatment was signifi-cantly higher than that of the control group,and there had statistical difference(P<0.05).The occurrence of adverse reaction of the 2 groups had no statistical difference (P>0.05).Conclusion Bevacizumab combined with docetaxel,5-FU and cisplatin chemotherapy for advanced gastric cancer is effective,improve the quality of life of patients and tolerability.It has important clini-cal value.