国际眼科杂志
國際眼科雜誌
국제안과잡지
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
2015年
2期
323-325
,共3页
板层角膜移植%角膜溃疡%甘油
闆層角膜移植%角膜潰瘍%甘油
판층각막이식%각막궤양%감유
lamellar keratoplasty%corneal ulcers%glycerin
目的：：初步探讨全厚板层角膜移植术治疗铜绿假单胞菌感染性角膜溃疡的可行性、安全性和增视效果。方法：采用回顾性非对照研究,对临床确诊为铜绿假单胞菌感染的角膜溃疡且常规抗革兰氏阴性杆菌药物治疗、溃疡范围局限、濒临穿孔的患者25例25眼行全厚板层角膜移植术。术后第1 wk；第1,3,6,12,18 mo常规随访,观察角膜植片上皮愈合情况、有无感染复发、免疫排斥反应、植片透明度和最佳矫正视力等；术后第6 mo和第12 mo复查角膜内皮细胞密度。结果：术中无1例因后弹力层破裂而改行穿透性角膜移植术；仅1例在术后1 mo出现细菌感染,再次细菌培养未培养出铜绿假单胞菌,其余24例平均随访14±6mo,角膜植片均透明,治愈率为96%。术后第6mo,有16例术眼最佳矫正视力≥4.5,其中3例≥4.8。术后第6mo,平均角膜内皮细胞密度为2425±278个/mm2；术后第12mo为2257±326个/mm2。结论：全厚板层角膜移植术是一种治疗铜绿假单胞菌感染性角膜溃疡的有效手段,甘油保存的干燥角膜材料能够达到增视效果。
目的：：初步探討全厚闆層角膜移植術治療銅綠假單胞菌感染性角膜潰瘍的可行性、安全性和增視效果。方法：採用迴顧性非對照研究,對臨床確診為銅綠假單胞菌感染的角膜潰瘍且常規抗革蘭氏陰性桿菌藥物治療、潰瘍範圍跼限、瀕臨穿孔的患者25例25眼行全厚闆層角膜移植術。術後第1 wk；第1,3,6,12,18 mo常規隨訪,觀察角膜植片上皮愈閤情況、有無感染複髮、免疫排斥反應、植片透明度和最佳矯正視力等；術後第6 mo和第12 mo複查角膜內皮細胞密度。結果：術中無1例因後彈力層破裂而改行穿透性角膜移植術；僅1例在術後1 mo齣現細菌感染,再次細菌培養未培養齣銅綠假單胞菌,其餘24例平均隨訪14±6mo,角膜植片均透明,治愈率為96%。術後第6mo,有16例術眼最佳矯正視力≥4.5,其中3例≥4.8。術後第6mo,平均角膜內皮細胞密度為2425±278箇/mm2；術後第12mo為2257±326箇/mm2。結論：全厚闆層角膜移植術是一種治療銅綠假單胞菌感染性角膜潰瘍的有效手段,甘油保存的榦燥角膜材料能夠達到增視效果。
목적：：초보탐토전후판층각막이식술치료동록가단포균감염성각막궤양적가행성、안전성화증시효과。방법：채용회고성비대조연구,대림상학진위동록가단포균감염적각막궤양차상규항혁란씨음성간균약물치료、궤양범위국한、빈림천공적환자25례25안행전후판층각막이식술。술후제1 wk；제1,3,6,12,18 mo상규수방,관찰각막식편상피유합정황、유무감염복발、면역배척반응、식편투명도화최가교정시력등；술후제6 mo화제12 mo복사각막내피세포밀도。결과：술중무1례인후탄력층파렬이개행천투성각막이식술；부1례재술후1 mo출현세균감염,재차세균배양미배양출동록가단포균,기여24례평균수방14±6mo,각막식편균투명,치유솔위96%。술후제6mo,유16례술안최가교정시력≥4.5,기중3례≥4.8。술후제6mo,평균각막내피세포밀도위2425±278개/mm2；술후제12mo위2257±326개/mm2。결론：전후판층각막이식술시일충치료동록가단포균감염성각막궤양적유효수단,감유보존적간조각막재료능구체도증시효과。
To explore the feasibility, safety and effect of the full-thickness lamellar keratoplasty for the treatment of pseudomonas aeruginosa corneal ulcer.METHODS: Based on a retrospective non-controlled study, 25 patients were given the full-thickness lamellar keratoplasty for clinical diagnosis of pseudomonas aeruginosa infection and corneal ulcer medication conventional anti-gram-negative bacteria. Routine follow-up were carried out at postoperative 1wk; 1, 3, 6, 12, 18mo to observe the situation of corneal epithelial healing, recurrent infection, immune rejection, graft transparency and best corrected visual acuity, etc. At the 6 and 12mo postoperative, corneal endothelial cell density was reexamined. RESULTS: No patients because of Descemet's membrane rupture underwent penetrating keratoplasty surgery: One only in cases of bacterial infection after 1mo, once again did not cultivate a culture of bacteria pseudomonas aeruginosa, and the remaining 24 cases average follow - up 14 ± 6mo, corneal graft were transparent, the cure rate was 96%. At the sixth month after surgery, there were 16 cases of eye surgery best corrected visual acuity ≥4. 5, of which 3 cases ≥4. 8. At the sixth month after surgery, the average corneal endothelial cell density 2 425 ± 278/mm2; At 12mo postoperatively, it was 2257± 326/mm2.CONCLUSlON: Full-thickness lamellar keratoplasty is an effective method of pseudomonas aeruginosa infection in the treatment of corneal ulcers, corneal drying material glycerol can be achieved by visual effects.
