CAJ | 학술논문

目的：：观察人工泪液联合普拉洛芬滴眼液治疗小梁切除术后合并轻中度干眼症的临床疗效。方法：前瞻性研究。对我院2013-11/2014-06就诊的小梁切除术后合并干眼症的病例63例63眼,按就诊顺序,随机分为观察组和对照组,观察组采用人工泪液联合普拉洛芬点眼治疗,对照组采用人工泪液治疗。分别于治疗前、治疗后1,2,4wk,对症状、体征进行评分,并观察泪膜破裂时间( BUT )、泪液分泌试验( SⅠt )、荧光素染色( FL),比较每组治疗前、后效果差异。结果：用药第2 wk后,观察组感觉性症状好转,评分差异有统计学意义(P<0.05),两组的角膜荧光染色评分差异均有统计学意义(P<0.05)；4wk后,两组感觉性症状及观察组眼表体征均有好转,评分差异有统计学意义(P<0.05),观察组的泪膜破裂时间及两组的角膜荧光素染色评分差异均有统计学意义(P<0.05)。结论：人工泪液联合普拉洛芬滴眼液治疗小梁切除术后合并轻中度干眼症效果良好。
목적：：관찰인공루액연합보랍락분적안액치료소량절제술후합병경중도간안증적림상료효。방법：전첨성연구。대아원2013-11/2014-06취진적소량절제술후합병간안증적병례63례63안,안취진순서,수궤분위관찰조화대조조,관찰조채용인공루액연합보랍락분점안치료,대조조채용인공루액치료。분별우치료전、치료후1,2,4wk,대증상、체정진행평분,병관찰루막파렬시간( BUT )、루액분비시험( SⅠt )、형광소염색( FL),비교매조치료전、후효과차이。결과：용약제2 wk후,관찰조감각성증상호전,평분차이유통계학의의(P<0.05),량조적각막형광염색평분차이균유통계학의의(P<0.05)；4wk후,량조감각성증상급관찰조안표체정균유호전,평분차이유통계학의의(P<0.05),관찰조적루막파렬시간급량조적각막형광소염색평분차이균유통계학의의(P<0.05)。결론：인공루액연합보랍락분적안액치료소량절제술후합병경중도간안증효과량호。
AlM:To evaluate the efficacy of combined pranoprofen eye drops and artificial tears on the treatment of mild to moderate dry eye syndrome after trabbeculectomy.METHODS:This prospective case control study included 63 cases (63 eyes) of patients with mild to moderate dry eye syndrome after trabbeculectomy in our hospital from November 2013 to June 2013. All subjects were randomly divided into two groups. Observation group was treated with combined pranoprofen eye drops and artificial tears and control group received simple artificial tears marking the eyes at 1, 2, 4wk. The patient's symptoms, signs, BUT, S▏t, and FL were observed before treatment and 1, 2, 4wk after treatment.RESULTS: After 2wk, the symptoms of observation group were improved, there was statistically significant difference (P<0. 05). FL difference of each group was statistically significant ( P<0. 05 ); After 4wk, symptoms and signs were improved. There was statistically significant difference ( P < 0. 05 ). The BUT of the observation group and corneal FL scores of two groups showed significant differences (P<0. 05). CONCLUSlON: Artificial tears joint pranoprofen eye drops has good curative effect in the treatment of mild to moderate dry eye syndrome after trabbeculectomy.