CAJ | 학술논문

本文回顾喷他佐辛在麻醉围术期、急性疼痛及慢性疼痛中的临床应用进展。检索并分析喷他佐辛的药效学、药代动力学及安全性评价的相关临床数据，发现喷他佐辛在作为手术前或麻醉前给药、诱导麻醉或维持麻醉的辅助用药时，可减少其他药物引起的不良反应。该药对术后急性疼痛镇痛疗效确切，不良反应发生率较低。长期注射喷他佐辛可产生药物依赖性，并引起注射部位皮肤和软组织病变。
본문회고분타좌신재마취위술기、급성동통급만성동통중적림상응용진전。검색병분석분타좌신적약효학、약대동역학급안전성평개적상관림상수거，발현분타좌신재작위수술전혹마취전급약、유도마취혹유지마취적보조용약시，가감소기타약물인기적불량반응。해약대술후급성동통진통료효학절，불량반응발생솔교저。장기주사분타좌신가산생약물의뢰성，병인기주사부위피부화연조직병변。
This review collected the recent clinical application of pen-tazocine in preoperative anesthesia , acute pain and chronic pain.Data of pharmacodynamics , pharmacokinetics and safety evaluation related to pentazocine were retrieved and analyzed.Pentazocin can decrease the in-cidence of adverse drug reactions when as additional analgesics adminis-trated either before anesthesia or during anesthesia induction and main -tenance.The clinical efficacy of pentazocine in postoperative acute pain has been confirmed , with a low incidence of adverse reaction.Prolonged injection of pentazocine may cause drug dependence leading to lesions in skin and soft tissue.