CAJ | 학술논문

沃替西汀（ vortioxetine ）临床用于重性抑郁障碍的治疗，其主要作用机制与中枢神经系统（ CNS）抑制5－羟色胺（5－HT）再摄取、增强5－HT活性相关。文中对沃替西汀的作用机制、药效学、药代动力学、药物相互作用、临床评价和安全性等进行综述。
옥체서정（ vortioxetine ）림상용우중성억욱장애적치료，기주요작용궤제여중추신경계통（ CNS）억제5－간색알（5－HT）재섭취、증강5－HT활성상관。문중대옥체서정적작용궤제、약효학、약대동역학、약물상호작용、림상평개화안전성등진행종술。
Vortioxetine is used for the treatment of major depressive disorder.The mechanism of the antidepressant effect of vortioxetine is thought to be related to its enhancement of serotonergic activity in the cen -tral nervous system ( CNS ) through inhibition of the reuptake of serotonin (5-HT).In this paper, we reviewed the mechanism , pharmacology, pharmacokinetics , drug -drug interactions , clinical studies and safety evaluation of vortioxetine.