CAJ | 학술논문

目的：评价小剂量甲基睾丸素联合米非司酮治疗围绝经期功能性子宫出血（ FUB）的疗效及对激素水平的影响。方法56例FUB患者刮宫后第1天开始服用米非司酮25 mg，甲基睾丸素5 mg，每天1次，共服用90 d，停用米非司酮后继续服用甲基睾丸素15 d后停药。测量治疗前后患者子宫内膜厚度和女性激素变化情况，随访记录2年月经情况。结果治疗后患者子宫内膜厚度显著降低（P＜0.05）；治疗后雌激素（E）和孕激素（P）水平明显下降（P＜0.05）；56例患者均已闭经，治疗后9例月经正常，14例月经稀少，33例绝经。随访2年，8例患者再次出现腹痛、阴道不规则流血等症状，复发率为14.3％。结论小剂量甲基睾丸素联合米非司酮治疗围绝经期FUB，可显著降低子宫内膜厚度，临床疗效满意，药物不良反应轻微。
목적：평개소제량갑기고환소연합미비사동치료위절경기공능성자궁출혈（ FUB）적료효급대격소수평적영향。방법56례FUB환자괄궁후제1천개시복용미비사동25 mg，갑기고환소5 mg，매천1차，공복용90 d，정용미비사동후계속복용갑기고환소15 d후정약。측량치료전후환자자궁내막후도화녀성격소변화정황，수방기록2년월경정황。결과치료후환자자궁내막후도현저강저（P＜0.05）；치료후자격소（E）화잉격소（P）수평명현하강（P＜0.05）；56례환자균이폐경，치료후9례월경정상，14례월경희소，33례절경。수방2년，8례환자재차출현복통、음도불규칙류혈등증상，복발솔위14.3％。결론소제량갑기고환소연합미비사동치료위절경기FUB，가현저강저자궁내막후도，림상료효만의，약물불량반응경미。
Objective To evaluate the clinical efficacy of methyl testos-terone combined with mifepristone on hormone and perimenopausal func-tional uterine bleeding ( FUB).Methods Fifty-six patients with FUB received methyl testosterone 5 mg qd for 90 days and mifepristone 25 mg qd for 105 days.The endometrial thickness and hormonal were measured before and after the treatment.The data of menstruation were recorded in two-year follow -up.Results The endometrial thickness was signifi-cantly decreased after the treatment ( P <0.05 ) and the serum estrogen and progesterone were much lower after treatment than that of before treatment(P<0.05).During the period of treatment , all of the fifty -six patients occurred amenorrhea , 9 case with normal menstruation , 14 cases of menstrual scarce and 33 cases of menopause after treatment.With 2 -year follow -up, eight patients had abdominal pain again , irregular vaginal bleeding and other symptoms , and the recurrence rate was 14.3%.Conclusion Methyl testosterone combined with mifepris-tone in the treatment of FUB can significantly reduce the thickness of the endometrium with satisfactory clinical efficacy and mild adverse reactions .