中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2015年
2期
4-6,7
,共4页
大豆异黄酮%内膜增生%雌激素%雌激素受体
大豆異黃酮%內膜增生%雌激素%雌激素受體
대두이황동%내막증생%자격소%자격소수체
Soy isoflavones%Endometrial hyperplasia%Estrogen%Estrogen receptors
目的：探讨大豆异黄酮对球囊损伤模型兔颈动脉后再狭窄的预防。方法：建立兔右颈动脉球囊损伤模型，实验分单纯球囊损伤组（Inj）、去势后球囊损伤组（Ovx+Inj）、去势球囊损伤后补充雌激素组（Ovx+Inj+E2）、去势球囊损伤后补充大豆异黄酮组（Ovx+Inj+Iso），于28 d行彩超检查，监测损伤动脉内-中膜的厚度及内膜的光滑程度，后分组等数分别处死动物，分别计算损伤血管腔内膜/中膜面积比值。结果：Inj组与Ovx+Inj组内膜、中膜增厚明显，管腔狭窄明显，Ovx+Inj+E2组和Ovx+Inj+Iso组各时段血管形态学分析显示内膜增生程度低于Inj组与Ovx+Inj组（P<0.05）。结论：大豆异黄酮可明显抑制损伤血管内膜增生及中膜平滑肌细胞增殖，发挥其血管保护作用。
目的：探討大豆異黃酮對毬囊損傷模型兔頸動脈後再狹窄的預防。方法：建立兔右頸動脈毬囊損傷模型，實驗分單純毬囊損傷組（Inj）、去勢後毬囊損傷組（Ovx+Inj）、去勢毬囊損傷後補充雌激素組（Ovx+Inj+E2）、去勢毬囊損傷後補充大豆異黃酮組（Ovx+Inj+Iso），于28 d行綵超檢查，鑑測損傷動脈內-中膜的厚度及內膜的光滑程度，後分組等數分彆處死動物，分彆計算損傷血管腔內膜/中膜麵積比值。結果：Inj組與Ovx+Inj組內膜、中膜增厚明顯，管腔狹窄明顯，Ovx+Inj+E2組和Ovx+Inj+Iso組各時段血管形態學分析顯示內膜增生程度低于Inj組與Ovx+Inj組（P<0.05）。結論：大豆異黃酮可明顯抑製損傷血管內膜增生及中膜平滑肌細胞增殖，髮揮其血管保護作用。
목적：탐토대두이황동대구낭손상모형토경동맥후재협착적예방。방법：건립토우경동맥구낭손상모형，실험분단순구낭손상조（Inj）、거세후구낭손상조（Ovx+Inj）、거세구낭손상후보충자격소조（Ovx+Inj+E2）、거세구낭손상후보충대두이황동조（Ovx+Inj+Iso），우28 d행채초검사，감측손상동맥내-중막적후도급내막적광활정도，후분조등수분별처사동물，분별계산손상혈관강내막/중막면적비치。결과：Inj조여Ovx+Inj조내막、중막증후명현，관강협착명현，Ovx+Inj+E2조화Ovx+Inj+Iso조각시단혈관형태학분석현시내막증생정도저우Inj조여Ovx+Inj조（P<0.05）。결론：대두이황동가명현억제손상혈관내막증생급중막평활기세포증식，발휘기혈관보호작용。
Objective:To investigate the effects of phytoestrogen isoflavone on balloon catheter-induced hyperplasia of carotid artery.Method:Forty-eight female New Zealand rabbits were randomly divided into four groups: control (balloon-induced carotid artery injury only); ovariectomy control (ovariectomy and carotid artery injury), oestrogen (ovariectomy, carotid artery injury and nilestriol, 5 mg/kg daily for 28 days), and isoflavone (ovariectomy, carotid artery injury and isoflavone 120 mg/kg daily for 28 days). The arterial wall thickness was assessed by coloured ultrasonography.Rusult:The medial layer thickness in the isoflavone group was less than in the ovariectomy control group (0.28±0.03 vs.0.35±0.04 mm,P<0.01), and the intimal/medial layer (I/M) ratio was the isoflavone group was also less than in the ovariectomy control group (16.85±3.79 vs.48.94±8.92,P<0.01).There was no statistically significant difference in the medial layer thickness or I/M ratio between the isoflavone and the oestrogen groups.Conclusion:Soybean isoflavones can play a role of protecting blood vessels to inhibit neointimal hyperplasia and the proliferation of vascular smooth muscle cell in Vascular injury .
