CAJ | 학술논문

目的：探讨吸入噻托溴铵对稳定期慢性阻塞性肺病（COPD）患者呼吸功能的影响。方法：选取本院呼吸与危重二科就诊的稳定期慢性阻塞性肺疾病患者68例，随机分成吸入噻托溴铵药物组和不吸入对照组，在治疗前、治疗后6周，分别测定并比较治疗前后两组的肺功能（FEV1、FEVl/FVC、FEVl%预计值）和血清炎性介质（IL-8、TNF-α）的浓度。结果：（1）两组治疗前FEV1、FEVl/FVC、FEVl%预计值、IL-8、TNF-α比较，差异均无统计学意义（P>0.05）。（2）治疗第6周末时，两组FEVl、FEVl/FVC、FEVl%预计值均高于治疗前，差异有统计学意义（P<0.01或P<0.05），炎性介质IL-8、TNF-α均低于治疗前（P<0.01），且治疗组比对照组改善更加明显（P<0.01）。结论：吸入噻托溴铵可明显改善慢性阻塞性肺疾病患者的肺功能，降低IL-8、TNF-α水平，减轻气道炎症，延缓肺功能恶化。
목적：탐토흡입새탁추안대은정기만성조새성폐병（COPD）환자호흡공능적영향。방법：선취본원호흡여위중이과취진적은정기만성조새성폐질병환자68례，수궤분성흡입새탁추안약물조화불흡입대조조，재치료전、치료후6주，분별측정병비교치료전후량조적폐공능（FEV1、FEVl/FVC、FEVl%예계치）화혈청염성개질（IL-8、TNF-α）적농도。결과：（1）량조치료전FEV1、FEVl/FVC、FEVl%예계치、IL-8、TNF-α비교，차이균무통계학의의（P>0.05）。（2）치료제6주말시，량조FEVl、FEVl/FVC、FEVl%예계치균고우치료전，차이유통계학의의（P<0.01혹P<0.05），염성개질IL-8、TNF-α균저우치료전（P<0.01），차치료조비대조조개선경가명현（P<0.01）。결론：흡입새탁추안가명현개선만성조새성폐질병환자적폐공능，강저IL-8、TNF-α수평，감경기도염증，연완폐공능악화。
Objective:To investigate the effects of inhaled Tiotropium on pulmonary function results in patients with stable chronic obstructive pulmonary disease(COPD).Method:68 COPD patients were randomly divided into experimental group(tiotropium group) and control group.The pulmonary function(FEVl,FEVl/FVC,FEVl%) and infiammatory cytokines(IL-8,TNF-α) were measured both before and 6 weeks after inhalation.Result:(1)There were no significant differences in the values of forced expiratory volume in FEV1,FEV1/FVC,FEV1%,IL-8 and TNF-α before treatment between two groups (P>0.05).(2)These were significantly improved in the values of forced expiratory volume in FEV1, FEV1/FVC,FEV1%(P<0.01 orP<0.05),the levels of IL-8,TNF-αin induced sputum can be significantly decreased between two groups(P<0.01),and after treatment the experimental group were better than the control group(P<0.01).Conclusion:Inhaled tiotropium can significantly improve the pulmonary functions,reduce the levels of inflammatory cytokines and airway inflammation in the treatment of COPD patients at stable stage.