中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2015年
2期
32-34,35
,共4页
布托啡诺%依托咪酯%肌阵挛
佈託啡諾%依託咪酯%肌陣攣
포탁배낙%의탁미지%기진련
Butorphanol%Etomidate%Myoclonus
目的：探讨预注布托啡诺对预防依托咪酯导致肌阵挛的效果。方法：拟在全麻下择期手术患者180例，ASA Ⅰ或Ⅱ级，男85例，女95例，年龄20~65岁，体重42~59 kg，随机分为布托啡诺组（B组）、舒芬太尼组（S组）和对照组（N组），每组各60例。B组给予布托啡诺20μg/kg（总量不大于2 mg）；S组给予舒芬太尼0.2μg/kg、N组给予同容积的生理盐水，1 min后三组患者均静注依托咪酯0.3 mg/kg，注射时间30 s，并持续观察2 min，观察痉挛发生情况和评估严重程度。结果：诱导期间三组患者的BP、HR差异无统计学意义，所有患者SpO2>97%；与N组比较，B组、S组患者肌阵挛1、2、3级例数明显减少，肌阵挛发生率明显降低（P<0.05）。结论：预注20μg/kg布托啡诺可有效减少依托咪酯诱导时导致的肌阵挛发生。
目的：探討預註佈託啡諾對預防依託咪酯導緻肌陣攣的效果。方法：擬在全痳下擇期手術患者180例，ASA Ⅰ或Ⅱ級，男85例，女95例，年齡20~65歲，體重42~59 kg，隨機分為佈託啡諾組（B組）、舒芬太尼組（S組）和對照組（N組），每組各60例。B組給予佈託啡諾20μg/kg（總量不大于2 mg）；S組給予舒芬太尼0.2μg/kg、N組給予同容積的生理鹽水，1 min後三組患者均靜註依託咪酯0.3 mg/kg，註射時間30 s，併持續觀察2 min，觀察痙攣髮生情況和評估嚴重程度。結果：誘導期間三組患者的BP、HR差異無統計學意義，所有患者SpO2>97%；與N組比較，B組、S組患者肌陣攣1、2、3級例數明顯減少，肌陣攣髮生率明顯降低（P<0.05）。結論：預註20μg/kg佈託啡諾可有效減少依託咪酯誘導時導緻的肌陣攣髮生。
목적：탐토예주포탁배낙대예방의탁미지도치기진련적효과。방법：의재전마하택기수술환자180례，ASA Ⅰ혹Ⅱ급，남85례，녀95례，년령20~65세，체중42~59 kg，수궤분위포탁배낙조（B조）、서분태니조（S조）화대조조（N조），매조각60례。B조급여포탁배낙20μg/kg（총량불대우2 mg）；S조급여서분태니0.2μg/kg、N조급여동용적적생리염수，1 min후삼조환자균정주의탁미지0.3 mg/kg，주사시간30 s，병지속관찰2 min，관찰경련발생정황화평고엄중정도。결과：유도기간삼조환자적BP、HR차이무통계학의의，소유환자SpO2>97%；여N조비교，B조、S조환자기진련1、2、3급례수명현감소，기진련발생솔명현강저（P<0.05）。결론：예주20μg/kg포탁배낙가유효감소의탁미지유도시도치적기진련발생。
Objective:To investigate influence of pre-injection Butorphanol on myoclonus caused by Etomidate during induction of general anesthesia.Method:To be under general anesthesia for elective surgery were 180 cases, ASAⅠ or Ⅱ, male 85 cases, female 95 cases, aged 20 to 65 years old, weighing 42-59 kg, were randomly divided into butorphanol group (group B), Sufentanil group (S group) and control group (N group), 60 cases in each group. Group B received butorphanol 20 μg/kg (total not more than 2 mg); S group received sufentanil 0.2 μg/kg, N group given the same volume of saline, 1 min three groups of patients after intravenous injection of etomidate acetate 0.3 mg/kg, injection time 30 s and continued to observe for 2 min, spasm conditions was observed and the severity was assessed.Result:Of the three groups of patients during induction BP, HR difference was not statistically significant, all patients SpO2> 97%; compared with the N group, group B, S myoclonic patients significantly reduced the number of cases 1,2,3,muscle Array twin significantly lower incidence(P<0.05).Conclusion:Preinjection 20 μg/kg butorphanol can effectively reduce lead time etomidate induced myoclonus occur.
