中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2015年
2期
30-31,32
,共3页
急性颅脑损伤%H-FABP%动态监测
急性顱腦損傷%H-FABP%動態鑑測
급성로뇌손상%H-FABP%동태감측
Acute brain injury%H-FABP%Dynamic monitoring
目的：分析血清H-FABP的动态监测在急性颅脑损伤患者病情判断中的应用价值。方法：将2013年5月-2014年5月期间本院收诊的急性颅脑损伤患者按病情严重程度分为轻度组、中度组和重度组，分别纳入26、23、25例，另选择同期健康体检者20例为对照组。比较不同组间血清H-FABP水平变化，并对患者进行随访，比较不同预后患者间（重度残疾、中度残疾、恢复良好）间入院后24 h血清H-FABP水平差异。结果：急性颅脑损伤患者各个时间段血清H-FABP水平均显著高于对照组（P<0.05）；轻度组、中度组、重度组三组间血清H-FABP水平历时性变化有显著差异（P<0.05），血清H-FABP水平随着病情的加重而升高。血清H-FABP水平最高点出现在入院后1 d。不同预后的急性颅脑损伤患者入院后24 h血清H-FABP水平存在显著差异，预后越差者血清H-FABP水平越低（P<0.05）。结论：血清H-FABP水平与急性颅脑损伤患者病情呈正相关，对患者预后评估具有指导意义。
目的：分析血清H-FABP的動態鑑測在急性顱腦損傷患者病情判斷中的應用價值。方法：將2013年5月-2014年5月期間本院收診的急性顱腦損傷患者按病情嚴重程度分為輕度組、中度組和重度組，分彆納入26、23、25例，另選擇同期健康體檢者20例為對照組。比較不同組間血清H-FABP水平變化，併對患者進行隨訪，比較不同預後患者間（重度殘疾、中度殘疾、恢複良好）間入院後24 h血清H-FABP水平差異。結果：急性顱腦損傷患者各箇時間段血清H-FABP水平均顯著高于對照組（P<0.05）；輕度組、中度組、重度組三組間血清H-FABP水平歷時性變化有顯著差異（P<0.05），血清H-FABP水平隨著病情的加重而升高。血清H-FABP水平最高點齣現在入院後1 d。不同預後的急性顱腦損傷患者入院後24 h血清H-FABP水平存在顯著差異，預後越差者血清H-FABP水平越低（P<0.05）。結論：血清H-FABP水平與急性顱腦損傷患者病情呈正相關，對患者預後評估具有指導意義。
목적：분석혈청H-FABP적동태감측재급성로뇌손상환자병정판단중적응용개치。방법：장2013년5월-2014년5월기간본원수진적급성로뇌손상환자안병정엄중정도분위경도조、중도조화중도조，분별납입26、23、25례，령선택동기건강체검자20례위대조조。비교불동조간혈청H-FABP수평변화，병대환자진행수방，비교불동예후환자간（중도잔질、중도잔질、회복량호）간입원후24 h혈청H-FABP수평차이。결과：급성로뇌손상환자각개시간단혈청H-FABP수평균현저고우대조조（P<0.05）；경도조、중도조、중도조삼조간혈청H-FABP수평력시성변화유현저차이（P<0.05），혈청H-FABP수평수착병정적가중이승고。혈청H-FABP수평최고점출현재입원후1 d。불동예후적급성로뇌손상환자입원후24 h혈청H-FABP수평존재현저차이，예후월차자혈청H-FABP수평월저（P<0.05）。결론：혈청H-FABP수평여급성로뇌손상환자병정정정상관，대환자예후평고구유지도의의。
Objective:To analyze the value of the application of dynamic monitoring of serum H-FABP in the determination of acute brain injury patient's condition.Method:Patients with acute brain injury in our hospital from May 2013 to May 2014 were divided into the mild, moderate group and severe group according to the severity, included 26 cases, 23 cases and 25 cases. Other 30 cases of healthy were chosen as the control group. The changes of serum H-FABP level of different groups were compared, and they were taken for following up. The differences of 24 hours after hospital admission between serum H-FABP level for different prognosis (severe disability, moderate disability, good recovery) were compared.Result:The Serum H-FABP levels of various time periods of the acute brain injury group were significantly higher than the control group(P<0.05).The changes of serum H-FABP level among the three groups lasted mild group,moderate group and severe group were with significant differences(P<0.05).The serum H-FABP levels increased with the disease worsen. The highest point of serum levels of H-FABP occurred 1 day after admission.The serum H-FABP levels 24 h after hospitalization for acute brain injury patients with different prognosis were with significant differences,the lower of the serum H-FABP level,the worse of the prognosis(P<0.05).Conclusion:Serum H-FABP level in patients is positively correlated with the situation of acute brain injury,and it has instructive significance for prognosis.
