中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2015年
2期
24-26
,共3页
李合云%郭正红%丁连鹤%金朱
李閤雲%郭正紅%丁連鶴%金硃
리합운%곽정홍%정련학%금주
碳酸氢钠%制霉菌素%鹅口疮%临床观察
碳痠氫鈉%製黴菌素%鵝口瘡%臨床觀察
탄산경납%제매균소%아구창%림상관찰
Sodium bicarbonate%Nystatin%Pediatric thrush%Clinical effect
目的：研究碳酸氢钠联合制霉菌素治疗小儿鹅口疮的临床效果，为该类疾病的治疗提供依据。方法：对2010年12月-2013年9月本院入院治疗的242例0~6个月鹅口疮小儿患者进行了研究，随机分为两组，每组各121例。对照组患儿单独涂布制霉菌素，治疗组患儿在对照组治疗基础上，加用2%的碳酸氢钠涂布于患处，每天涂布3~4次，观察并记录两组患儿临床症状消失时间，比较复发率和临床总有效率，并比较两组患儿的不良反应。结果：治疗组患儿在1~2 d内白斑消失例数明显高于对照组，差异有统计学意义（P<0.05）；治疗组患儿3个月及6个月的复发率分别为2.2%和4.7%，明显低于对照组10.9%和24.4%，两组比较差异有统计学意义（P<0.05）；治疗组临床总有效率为96.7%，明显高于对照组的81.1%，差异有统计学意义（P<0.05）；治疗组患儿皮疹、呕吐等不良反应发生率明显低于对照组，差异有统计学意义（P<0.05）。结论：碳酸氢钠联合制霉菌素治疗小儿鹅口疮临床效果显著，同等治疗时间内，临床症状改善更明显，并且复发率低，临床效果显著，患儿耐受性好，值得临床推广应用。
目的：研究碳痠氫鈉聯閤製黴菌素治療小兒鵝口瘡的臨床效果，為該類疾病的治療提供依據。方法：對2010年12月-2013年9月本院入院治療的242例0~6箇月鵝口瘡小兒患者進行瞭研究，隨機分為兩組，每組各121例。對照組患兒單獨塗佈製黴菌素，治療組患兒在對照組治療基礎上，加用2%的碳痠氫鈉塗佈于患處，每天塗佈3~4次，觀察併記錄兩組患兒臨床癥狀消失時間，比較複髮率和臨床總有效率，併比較兩組患兒的不良反應。結果：治療組患兒在1~2 d內白斑消失例數明顯高于對照組，差異有統計學意義（P<0.05）；治療組患兒3箇月及6箇月的複髮率分彆為2.2%和4.7%，明顯低于對照組10.9%和24.4%，兩組比較差異有統計學意義（P<0.05）；治療組臨床總有效率為96.7%，明顯高于對照組的81.1%，差異有統計學意義（P<0.05）；治療組患兒皮疹、嘔吐等不良反應髮生率明顯低于對照組，差異有統計學意義（P<0.05）。結論：碳痠氫鈉聯閤製黴菌素治療小兒鵝口瘡臨床效果顯著，同等治療時間內，臨床癥狀改善更明顯，併且複髮率低，臨床效果顯著，患兒耐受性好，值得臨床推廣應用。
목적：연구탄산경납연합제매균소치료소인아구창적림상효과，위해류질병적치료제공의거。방법：대2010년12월-2013년9월본원입원치료적242례0~6개월아구창소인환자진행료연구，수궤분위량조，매조각121례。대조조환인단독도포제매균소，치료조환인재대조조치료기출상，가용2%적탄산경납도포우환처，매천도포3~4차，관찰병기록량조환인림상증상소실시간，비교복발솔화림상총유효솔，병비교량조환인적불량반응。결과：치료조환인재1~2 d내백반소실례수명현고우대조조，차이유통계학의의（P<0.05）；치료조환인3개월급6개월적복발솔분별위2.2%화4.7%，명현저우대조조10.9%화24.4%，량조비교차이유통계학의의（P<0.05）；치료조림상총유효솔위96.7%，명현고우대조조적81.1%，차이유통계학의의（P<0.05）；치료조환인피진、구토등불량반응발생솔명현저우대조조，차이유통계학의의（P<0.05）。결론：탄산경납연합제매균소치료소인아구창림상효과현저，동등치료시간내，림상증상개선경명현，병차복발솔저，림상효과현저，환인내수성호，치득림상추엄응용。
Objective:To study the clinical effect sodium bicarbonate with nystatin on the treatment of pediatric thrush, for the proof of this kind of disease.Method: A total of 242 cases of 0 to 6 months thrush pediatric patients from December 2010 to September 2013in our hospital were randomly divided into two groups,121 cases in each group. The control group was coated nystatin powder, the treatment groups was treated by 20% of sodium bicarbonate for 3-4 times a day on the base of the nystatin powder, the clinical symptoms disappear time, the recurrence rate, the total clinical effect and the adverse effect were observed and compared.Result: The time of vitiligo disappear of 1-2 days in treatment group significant higher than the control group,the difference was statistically significant(P<0.05); the treatment group of recurrence rate in 3 months and 6 months were 2.2% and 4.7%, they were significant lower than the control group of 10.9% and 24.4%,the difference was statistically significant(P<0.05); treatment group of total effective rate was 96.7% and the control group of total effective rate was 81.1%, the difference was statistically significant(P<0.05); the rash and vomiting were significant lower than the control group, the difference was statistically significant(P<0.05). Conclusion: The effect of sodium bicarbonate with nystatin on pediatric thrush is remarkable, the symptom in clinical is improved, the recurrence is high, the clinical effect is better, the tolerance is well. It is worth for clinical use.
