CAJ | 학술논문

目的：了解缬沙坦联合泼尼松、吗替麦考酚酯（MMF）治疗小儿难治性肾病综合征的疗效。方法：54例符合难治性肾病综合征诊断标准的患儿，随机选取36例为治疗组，采用缬沙坦联合泼尼松、吗替麦考酚酯（MMF）治疗12周，对照组18例，仅使用泼尼松、吗替麦考酚酯联合治疗，定期复查尿常规、24 h尿蛋白定量、肝、肾功能等，观察两组近期疗效。结果：治疗组治疗3个月后总有效率为94.5%，对照组为83.3％，两组疗效比较差异有统计学意义（P<0.05）。结论：缬沙坦联合泼尼松、MMF治疗小儿难治性肾病综合征具有更好的疗效。
목적：료해힐사탄연합발니송、마체맥고분지（MMF）치료소인난치성신병종합정적료효。방법：54례부합난치성신병종합정진단표준적환인，수궤선취36례위치료조，채용힐사탄연합발니송、마체맥고분지（MMF）치료12주，대조조18례，부사용발니송、마체맥고분지연합치료，정기복사뇨상규、24 h뇨단백정량、간、신공능등，관찰량조근기료효。결과：치료조치료3개월후총유효솔위94.5%，대조조위83.3％，량조료효비교차이유통계학의의（P<0.05）。결론：힐사탄연합발니송、MMF치료소인난치성신병종합정구유경호적료효。
Objective:To explore the therapeutic effect of valsartan combination treatment with mycophenolate mofetil and prednison in refractory nephropathy syndrome.Method:54 patients with primary refractory nephropathy syndrome were randomly divided into treatment group and control group. 36 cases of treatment group were treated by valsartan combined with MMF and prednisone, and 18 cases of the control groups were only threated with MMF and prednisone.The blood test, 24 h quantitation of proteinuria, liver function and renal function periodically were observed. Result:3 months later,the total effective rate were 94.5% and 83.3% respectively.Conclusion: Valsartan combined with MMF and prednisone is effective on child primary refractory nephropathy syndrome.It is a kind of promising clinical treatment of this disease at present.