磁共振成像
磁共振成像
자공진성상
CHINESE JOURNAL OF MAGNETIC RESONANCE IMAGING
2015年
1期
10-14
,共5页
谢生辉%牛广明%高阳%乔鹏飞
謝生輝%牛廣明%高暘%喬鵬飛
사생휘%우엄명%고양%교붕비
抑郁症%功能磁共振成像
抑鬱癥%功能磁共振成像
억욱증%공능자공진성상
Depression%Functional magnetic resonance imaging
目的利用静息态功能磁共振成像(resting-state functional MRI,rfMRI)技术,探索抑郁症患者异常脑功能活动区域及抑郁心境对患者脑功能的影响。材料与方法对30例抑郁症患者[符合DSM-IV抑郁症的诊断标准,汉密尔顿抑郁量表(HAMD-17)评分≥17分]和30例健康志愿者行rfMRI扫描。使用局部一致性(regional homogeneity,ReHo)方法对比分析ReHo在抑郁症组与正常对照组之间的不同。结果抑郁症组与正常对照ReHo图组间分析:抑郁症组大脑的双侧部分额、颞、顶叶、双侧壳核、右侧尾状核、杏仁核、扣带回、小脑蚓部等脑区的ReHo显著高于正常对照组,而在双侧前额叶、楔前叶、舌回及小脑半球等脑区ReHo显著减低(P<0.001, K>10)。结论 ReHo方法可检出抑郁心境造成的局部脑组织BOLD信号同步性的改变,更客观地反映全脑的功能状态,有助于抑郁症的基础和临床研究。
目的利用靜息態功能磁共振成像(resting-state functional MRI,rfMRI)技術,探索抑鬱癥患者異常腦功能活動區域及抑鬱心境對患者腦功能的影響。材料與方法對30例抑鬱癥患者[符閤DSM-IV抑鬱癥的診斷標準,漢密爾頓抑鬱量錶(HAMD-17)評分≥17分]和30例健康誌願者行rfMRI掃描。使用跼部一緻性(regional homogeneity,ReHo)方法對比分析ReHo在抑鬱癥組與正常對照組之間的不同。結果抑鬱癥組與正常對照ReHo圖組間分析:抑鬱癥組大腦的雙側部分額、顳、頂葉、雙側殼覈、右側尾狀覈、杏仁覈、釦帶迴、小腦蚓部等腦區的ReHo顯著高于正常對照組,而在雙側前額葉、楔前葉、舌迴及小腦半毬等腦區ReHo顯著減低(P<0.001, K>10)。結論 ReHo方法可檢齣抑鬱心境造成的跼部腦組織BOLD信號同步性的改變,更客觀地反映全腦的功能狀態,有助于抑鬱癥的基礎和臨床研究。
목적이용정식태공능자공진성상(resting-state functional MRI,rfMRI)기술,탐색억욱증환자이상뇌공능활동구역급억욱심경대환자뇌공능적영향。재료여방법대30례억욱증환자[부합DSM-IV억욱증적진단표준,한밀이돈억욱량표(HAMD-17)평분≥17분]화30례건강지원자행rfMRI소묘。사용국부일치성(regional homogeneity,ReHo)방법대비분석ReHo재억욱증조여정상대조조지간적불동。결과억욱증조여정상대조ReHo도조간분석:억욱증조대뇌적쌍측부분액、섭、정협、쌍측각핵、우측미상핵、행인핵、구대회、소뇌인부등뇌구적ReHo현저고우정상대조조,이재쌍측전액협、설전협、설회급소뇌반구등뇌구ReHo현저감저(P<0.001, K>10)。결론 ReHo방법가검출억욱심경조성적국부뇌조직BOLD신호동보성적개변,경객관지반영전뇌적공능상태,유조우억욱증적기출화림상연구。
Objective:To explore the abnormal active area of brain function in patients with depression and the impact of depressive mood to the patient’s brain function using resting-state functional MRI(rfMRI) technology. Materials and Methods:30 patients with depression [live up to DSM-IV diagnostic criteria for depression, Hamilton Depression Scale (HAMD-17) score≥17 points] and 30 healthy volunteers were examed by rfMRI. The difference between depression and normal control group was analyzed using the method of regional homogeneity (ReHo). Results:ReHo was signiifcantly higher than the control group in the brain area of Bilateral part of the brain the amount of depression group, temporal, parietal, and bilateral putamen, right caudate nucleus, amygdala, cortex, cerebellar vermis, etc, while in the brain area of bilateral prefrontal cortex, precuneus, lingual gyrus and cerebellum, etc. reduced signiifcantly (P<0.001, K>10) on ReHo chart analysis of depression group and normal control group. Conclusions: ReHo method can detect synchronised changes of regional cerebral tissue BOLD signal caused by depressed mood, more objectively relfect the functional state of the whole brain, thereby contribute to basic and clinical research of patients with depression.