CAJ | 학술논문

目的：观察99Tc-MDP（云克）对骨性关节炎患者治疗前后症状、细胞因子水平、骨侵蚀修复及骨密度的变化情况，探讨云克治疗骨关节炎的临床价值。方法：选择我科2009年1月-2012年3月住院的106名骨关节炎患者；其中，男49例，女67例，平均年龄（62.5±14.2）岁；随机分为2组，传统治疗组和云克治疗组，分别进行治疗前的对关节疼痛数量，IL-1β、TNF-α水平和跟骨密度水平指标进行检测，观察治疗3周之后关节疼痛数量，IL-1β、TNF-α水平和骨关节面的骨侵蚀修复情况，并进行统计比较。结果：治疗前后两组间各项指标均具有统计学意义（P＜0.01）。结论：联合使用云克治疗骨关节炎，可以明显改善病情，降低细胞因子水平，促进骨关节面修复的作用。
목적：관찰99Tc-MDP（운극）대골성관절염환자치료전후증상、세포인자수평、골침식수복급골밀도적변화정황，탐토운극치료골관절염적림상개치。방법：선택아과2009년1월-2012년3월주원적106명골관절염환자；기중，남49례，녀67례，평균년령（62.5±14.2）세；수궤분위2조，전통치료조화운극치료조，분별진행치료전적대관절동통수량，IL-1β、TNF-α수평화근골밀도수평지표진행검측，관찰치료3주지후관절동통수량，IL-1β、TNF-α수평화골관절면적골침식수복정황，병진행통계비교。결과：치료전후량조간각항지표균구유통계학의의（P＜0.01）。결론：연합사용운극치료골관절염，가이명현개선병정，강저세포인자수평，촉진골관절면수복적작용。
Objective: To observed the changes of condition changes,cytokines(IL-1β, TNF-α) levels,bone erosion repair and bone mineral density , before and after 99Tc-MDP (MDP) treatment osteoarthritis and explore the clinicalvalue use of MDP treatment osteoarthritis. Methods: Select 106 patients hospitalized osteoarthritis in our department from January 2009 to March 2012 Among them , 49 males and 67 females, mean age (62.5±14.2)years,randomly divided into 2 groups,respectively, to maintain the originaltreatment group and the MDP group therapy for three weeks; The number of joint pain,IL-1β,TNF-α levels and level indicators with BMD were detected before treatment, observation and treatment of bone and joint pain quantity,IL-1β,TNF-α levels and bone and joint surfaces after 3 weeks erosion repair the situation and make statistical comparisons . Results:Indicators before and after treatment between the two groups were statistically significant (P<0.01). Conclusion:The combined use of cloud g treatment of osteoarthritis, can significantly improve the condition and reduce the levels of cytokines, promote articular surface repair.