CAJ | 학술논문

目的：检测寻常型银屑病伴发瘙痒患者表皮组胺H1和H2受体的表达，探讨两种组胺受体与瘙痒的关系。方法采用免疫组织化学法检测伴发瘙痒的寻常型银屑病皮损、非皮损患者23例及正常人10例的表皮中组胺受体的表达，采用CMIAS图像分析法进行半定量分析。结果银屑病瘙痒患者皮损表皮中组胺受体的表达水平明显高于非皮损（P＜0.05）和正常皮肤（P＜0.05），非皮损与正常皮肤间差异无统计学意义（P＞0.05）。结论组胺H1和H2受体在银屑病皮损表皮中表达升高，提示组胺受体可能参与了银屑病及其瘙痒的发病过程，这可能是治疗银屑病有效的药理学靶点。
목적：검측심상형은설병반발소양환자표피조알H1화H2수체적표체，탐토량충조알수체여소양적관계。방법채용면역조직화학법검측반발소양적심상형은설병피손、비피손환자23례급정상인10례적표피중조알수체적표체，채용CMIAS도상분석법진행반정량분석。결과은설병소양환자피손표피중조알수체적표체수평명현고우비피손（P＜0.05）화정상피부（P＜0.05），비피손여정상피부간차이무통계학의의（P＞0.05）。결론조알H1화H2수체재은설병피손표피중표체승고，제시조알수체가능삼여료은설병급기소양적발병과정，저가능시치료은설병유효적약이학파점。
ObjectiveTo detect the expression of H1R and H2R in epidermis of psoriasis vulgaris with pruritus and to investigate the role of two histamine receptors in the pathogenesis of psoriasis and its pruritus. MethodsImmunohistochemistry was carried out to detect the expression of H1R and H2R in lesional tissue, non-lesional tissue and normal skin tissue. The CMIAS image analysis system was used to perform semi-quantitative analysis.ResultsThe expression of H1R and H2R in lesional tissue was significantly higher than difference between non-lesional tissue and normal skin tissue (P>0.05).ConclusionThe expressions of H1R and H2R were up-regulated in lesions of pruritic patients with psoriasis. It suggested that they might be involved in the pathogenesis of psoriasis and its pruritus.