实用癌症杂志
實用癌癥雜誌
실용암증잡지
THE PRACTICAL JOURNAL OF CANCER
2015年
1期
133-135
,共3页
经腹经骶柱状切除技术%晚期%中低位直肠癌%复发%转移
經腹經骶柱狀切除技術%晚期%中低位直腸癌%複髮%轉移
경복경저주상절제기술%만기%중저위직장암%복발%전이
Abdominal sacral resection of cylindrical technology%Advanced%Medium-low rectal cancer%Recurrence%Me-tastasis
目的：探讨经腹经骶柱状切除技术对晚期中低位直肠癌综合治疗后复发和转移的影响。方法将100例晚期中低位直肠癌且可行手术治疗患者，按数字随机法分为观察组和对照组，每组50例。观察组采取经腹经骶柱状切除＋术中化疗＋术后放化疗，对照组采取经肛门局部切除＋术中化疗＋术后放化疗。术后随访5年，比较两组术后6个月、1年、3年和5年复发率和转移率以及无病生存率。结果观察组疗效显著率和治疗有效率分别为40％和96％，高于对照组（22％和84％），差异有统计学意义（P＜0．05）。观察组术后6个月、1年、3年和5年复发率分别为2％、2％、6％和10％，低于对照组的6％、8％、12％和18％，而观察组术后6个月、1年、3年和5年转移率分别为2％、4％、10％和14％，低于对照组的6％、10％、18％和22％，差异有统计学意义（P＜0．05）。观察组术后6个月、1年、3年和5年无病生存率分别为100％、96％、90％和82％，显著高于对照组的88％、80％、68％和54％，差异有统计学意义（ P＜0．01）。结论经腹经骶柱状切除术可有效减少晚期中低位直肠癌综合治疗后复发和转移的发生，提高患者的无病生存率，值得临床推广使用。
目的：探討經腹經骶柱狀切除技術對晚期中低位直腸癌綜閤治療後複髮和轉移的影響。方法將100例晚期中低位直腸癌且可行手術治療患者，按數字隨機法分為觀察組和對照組，每組50例。觀察組採取經腹經骶柱狀切除＋術中化療＋術後放化療，對照組採取經肛門跼部切除＋術中化療＋術後放化療。術後隨訪5年，比較兩組術後6箇月、1年、3年和5年複髮率和轉移率以及無病生存率。結果觀察組療效顯著率和治療有效率分彆為40％和96％，高于對照組（22％和84％），差異有統計學意義（P＜0．05）。觀察組術後6箇月、1年、3年和5年複髮率分彆為2％、2％、6％和10％，低于對照組的6％、8％、12％和18％，而觀察組術後6箇月、1年、3年和5年轉移率分彆為2％、4％、10％和14％，低于對照組的6％、10％、18％和22％，差異有統計學意義（P＜0．05）。觀察組術後6箇月、1年、3年和5年無病生存率分彆為100％、96％、90％和82％，顯著高于對照組的88％、80％、68％和54％，差異有統計學意義（ P＜0．01）。結論經腹經骶柱狀切除術可有效減少晚期中低位直腸癌綜閤治療後複髮和轉移的髮生，提高患者的無病生存率，值得臨床推廣使用。
목적：탐토경복경저주상절제기술대만기중저위직장암종합치료후복발화전이적영향。방법장100례만기중저위직장암차가행수술치료환자，안수자수궤법분위관찰조화대조조，매조50례。관찰조채취경복경저주상절제＋술중화료＋술후방화료，대조조채취경항문국부절제＋술중화료＋술후방화료。술후수방5년，비교량조술후6개월、1년、3년화5년복발솔화전이솔이급무병생존솔。결과관찰조료효현저솔화치료유효솔분별위40％화96％，고우대조조（22％화84％），차이유통계학의의（P＜0．05）。관찰조술후6개월、1년、3년화5년복발솔분별위2％、2％、6％화10％，저우대조조적6％、8％、12％화18％，이관찰조술후6개월、1년、3년화5년전이솔분별위2％、4％、10％화14％，저우대조조적6％、10％、18％화22％，차이유통계학의의（P＜0．05）。관찰조술후6개월、1년、3년화5년무병생존솔분별위100％、96％、90％화82％，현저고우대조조적88％、80％、68％화54％，차이유통계학의의（ P＜0．01）。결론경복경저주상절제술가유효감소만기중저위직장암종합치료후복발화전이적발생，제고환자적무병생존솔，치득림상추엄사용。
Objective To explore the influence of abdominal sacral resection of cylindrical technology on recurrence and metastasis of advanced medium-low rectal cancer after comprehensive treatment.Methods 100 patients with advanced medium-low rectal cancer and feasible surgical treatment were randomly divided into the observation group and the control group,50 cases in each group.The observation group was treated with abdominal sacral resection of cylindrical technology,chemotherapy in opera-tion and postoperative radiation and chemotherapy,while the control group was treated with anus local excision,chemotherapy in operation and postoperative radiation and chemotherapy.All the patients received postoperative 5-year follow-up.Curative effects, recurrence,metastasis rates and disease-free survival rates postoperative 6-month,1-year,3-year and 5-year of the two groups were compared.Results Significant treating effect and treatment efficiency rate in the observation group were 40%and 96%,respec-tively,which were higher than 22%and 84%of the control group,and the difference was statistically significant (P<0.05).6-month,1-year,3-year and 5-year recurrence rates in the observation group were 2%,2%,6% and 2%,respectively,which were lower than 6%,8%,6%and 18%of the control group,and 6-month,1-year,3-year and 5-year metastasis rates in the observation group were 2%,4%,10% and 4%,respectively,which was lower than 6%,10%,6% and 22% of the control group,and the differences were statistically significant (P<0.05).6-month,1-year,3-year and 5-year disease-free survival rates in the observa-tion group were 100%,96%,90%and 82%,respectively,which were significantly higher than 88%,80%,68%and 54%of the control group,and the difference was statistically significant (P<0.01).Conclusion Abdominal sacral resection of cylindrical technology can effectively reduce the recurrence and metastasis rate of advanced medium-low rectal cancer after comprehensive treatment,and improve disease-free survival rate,it is worthy of clinical promotion.
