CAJ | 학술논문

目的：分析16q12 rs3803662位点基因多态性与乳腺癌罹患风险的相关性。方法检索PubMed、 Ovid、Medline和Web of Science数据库的文献，应用Stata／SE 12．0对全部关于16q12 rs3803662基因多态性与乳腺癌易感性的研究结果进行异质性检验和效应值合并。结果检索到30篇相关文献，25篇纳入研究的文献中，累计病例69127例，对照95954例。总研究人群分析结果显示，与C等位基因相比，16q12 rs3803662位点T等位基因显著增加高加索人群、亚洲人群和混合人群乳腺癌的罹患风险。分层分析结果显示，与雌激素受体阴性乳腺癌患者相比，rs3803662 T等位基因显著增加雌激素受体阳性乳腺癌患者的罹患风险。与携带BRCA1基因突变的乳腺癌患者相比，rs3803662 T等位基因显著增加携带BRCA2基因突变乳腺癌患者的易感性。结论排除非洲人群，16q12 rs3803662位点T等位基因显著增加个体罹患乳腺癌风险。
목적：분석16q12 rs3803662위점기인다태성여유선암리환풍험적상관성。방법검색PubMed、 Ovid、Medline화Web of Science수거고적문헌，응용Stata／SE 12．0대전부관우16q12 rs3803662기인다태성여유선암역감성적연구결과진행이질성검험화효응치합병。결과검색도30편상관문헌，25편납입연구적문헌중，루계병례69127례，대조95954례。총연구인군분석결과현시，여C등위기인상비，16q12 rs3803662위점T등위기인현저증가고가색인군、아주인군화혼합인군유선암적리환풍험。분층분석결과현시，여자격소수체음성유선암환자상비，rs3803662 T등위기인현저증가자격소수체양성유선암환자적리환풍험。여휴대BRCA1기인돌변적유선암환자상비，rs3803662 T등위기인현저증가휴대BRCA2기인돌변유선암환자적역감성。결론배제비주인군，16q12 rs3803662위점T등위기인현저증가개체리환유선암풍험。
Objective To study the relationship between 16q12 rs3803662 polymorphisms and breast cancer susceptibil-ity.Methods PubMed,Ovid,Medline and Web of Science database were searched.Crude odds ratio ( OR) with 95%confidence interval ( CI) was used to assess the strength of association.Results A total of 25 studies including 69,127 cases and 95,954 controls were identified.Breast cancer risk was associated with 16q12 rs3803662 polymorphism when all studies were pooled into the meta-analysis (OR 1.20,95%CI 1.16-1.24).For rs3803662,stronger association was observed with ER+tumors (OR 1.23,95%CI 1.13-1.32) compared to ER–tumors (OR 1.08,95%CI 0.97-1.20) and a same condition occurred for the pol-ymorphism with PR+tumors (OR 1.26,95%CI 1.02-1.55) versus PR–tumors (OR 1.15,95%CI 0.90-1.46).When strati-fied by BRCA mutation status,stronger association was observed with BRCA2 carriers (OR 1.23,95%CI 1.05-1.44) than BRCA1 carriers (OR 1.09,95%CI 1.04-1.15).Conclusion The T-allele of 16q12 rs3803662 is risk factor associated with in-creased breast cancer susceptibility.