CAJ | 학술논문

目的：探讨胸腔积液肿瘤标志物联合检测在临床上的应用价值。方法选择42例恶性胸腔积液患者为试验组，同时选择同期检查的42例良性胸腔积液患者作为对照组，分别采用免疫化学发光法来对这些患者的CA125和CA153以及CA199、CEA水平进行联合检测，并对这些肿瘤标志物的水平与单独检测结果进行比较和分析。结果试验组患者的肿瘤标志物CA125和CA153以及CA199、CEA含量均明显高于对照组（ P＜0．05）。此外，试验组单项肿瘤标志物的检测敏感度要明显低于肿瘤标志物联合检测（ P＜0．05）。试验组中CEA、CA199、CA153的阳性率明显高于对照组（P＜0．01）；而2组CA125阳性率比较，P＞0．05。结论临床上，采用胸腔积液肿瘤标志物联合检测，能够有效地提高临床诊断敏感度，为患者合理地选择治疗方案以及及早、及时治疗，避免患者病情恶化。
목적：탐토흉강적액종류표지물연합검측재림상상적응용개치。방법선택42례악성흉강적액환자위시험조，동시선택동기검사적42례량성흉강적액환자작위대조조，분별채용면역화학발광법래대저사환자적CA125화CA153이급CA199、CEA수평진행연합검측，병대저사종류표지물적수평여단독검측결과진행비교화분석。결과시험조환자적종류표지물CA125화CA153이급CA199、CEA함량균명현고우대조조（ P＜0．05）。차외，시험조단항종류표지물적검측민감도요명현저우종류표지물연합검측（ P＜0．05）。시험조중CEA、CA199、CA153적양성솔명현고우대조조（P＜0．01）；이2조CA125양성솔비교，P＞0．05。결론림상상，채용흉강적액종류표지물연합검측，능구유효지제고림상진단민감도，위환자합리지선택치료방안이급급조、급시치료，피면환자병정악화。
Objective To explore the clinical value of combined detection of pleural effusions tumor markers.Methods 42 cases of malignant pleural effusion patients was the experimental group,42 cases of benign pleural effusion patients was the control group,the immune chemiluminescence method was used in combined detection of CA125,CA153,CA199,CEA levels,and the levels of tumor markers and single detection were compared.Results CA153,CA199 and CA125,CEA levels in the experi-mental group were significantly higher than those of the control group (P<0.05).In addition,detection sensitivity of single tumor markers was significantly lower than of combined tumor marker (P<0.05).Positive rates of CEA,CA199,CA153 in the experi-mental group was obviously higher than those of the control group (P<0.01);And CA125 positive rate of the 2 groups had no significant difference(P>0.05).Conclusion Clinically,joint pleural effusions tumor markers detection can effectively improve the clinical diagnostic sensitivity,timely and reasonable treatment can avoid deterioration.