CAJ | 학술논문

目的：应用基于纤维束示踪的空间统计分析（tract-based spatial statistcs， TBSS）方法，探讨青少年抑郁症患者大脑白质的变化。方法：收集年龄、性别、教育程度匹配的35例首发青少年抑郁症患者（抑郁组）和40例健康青少年（对照组），并对其进行全脑的 DTI 扫描，应用 TBSS 的方法比较两组间各向异性分数（fractional anisotropy， FA）、轴向扩散率（axial diffusivity，AD）、径向扩散率（radial diffusivity，RD）和平均扩散率（mean diffusivity， MD）的差异。结果：抑郁组脑白质微结构异常，与对照组相比，胼胝体体部的FA值降低（P ＜0．01），RD、MD值升高（P ＜0．01），AD值无明显变化（P ＞0．05）。抑郁症组胼胝体体部FA值与抑郁严重程度呈负相关（P ＜0．01）。结论：脑白质异常参与青少年抑郁症的发生过程，这些改变发生在疾病发生过程的早期。
목적：응용기우섬유속시종적공간통계분석（tract-based spatial statistcs， TBSS）방법，탐토청소년억욱증환자대뇌백질적변화。방법：수집년령、성별、교육정도필배적35례수발청소년억욱증환자（억욱조）화40례건강청소년（대조조），병대기진행전뇌적 DTI 소묘，응용 TBSS 적방법비교량조간각향이성분수（fractional anisotropy， FA）、축향확산솔（axial diffusivity，AD）、경향확산솔（radial diffusivity，RD）화평균확산솔（mean diffusivity， MD）적차이。결과：억욱조뇌백질미결구이상，여대조조상비，변지체체부적FA치강저（P ＜0．01），RD、MD치승고（P ＜0．01），AD치무명현변화（P ＞0．05）。억욱증조변지체체부FA치여억욱엄중정도정부상관（P ＜0．01）。결론：뇌백질이상삼여청소년억욱증적발생과정，저사개변발생재질병발생과정적조기。
Objective To investigate the changes of the white matter in adolescent depression by using the method of tract-based spatial statistics (TBSS). Methods We employed TBSS to examine WM microstructure in 35 treatment-naive adolescents with clinical depression and in 40 matched controls. By using the TBSS, we compared the difference of fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD) and mean diffusivity (MD) between theadolescent patients with depression and the controls. Results Our analysis revealed the abnormal WM microstructures in the clinically depressed adolescents. The whole-brain analysis revealed that patients, with lower FA values in the body of the corpus callosum (CC) (P < 0.01), had elevated RD and MD (P < 0.01), and preserved AD (P > 0.05). The FA values in the body of the corpus callosum was negatively correlated with the severity of depression (P < 0.01). Conclusions Our findings suggest that WM abnormalities are involved in the path-physiology of depression. Importantly , our findings show that these WM abnormalities present early in the course of the disorder.