CAJ | 학술논문

目的：探讨帕瑞昔布对大鼠全脑缺血再灌注损伤中学习和记忆能力的保护作用。方法：雄性Wistar大鼠随机分为S组、I／R组和I／R＋PA组，全脑缺血模型采用改良的Pulsinelli四血管法；再灌注72 h后连续行5 d Morris水迷宫实验评价其空间分辨学习和记忆能力；处死大鼠，灌注取脑行Nissl染色观察海马CA1区神经元的存活情况。结果：与I／R组相比，大鼠潜伏期I／R＋PA组明显缩短（P＜0．05），穿越平台次数和在目标象限的时间增多（P＜0．05），尼氏染色CA1区神经元死亡较少。结论：帕瑞昔布对大鼠全脑缺血再灌注损伤中学习和记忆能力具有一定的保护作用。
목적：탐토파서석포대대서전뇌결혈재관주손상중학습화기억능력적보호작용。방법：웅성Wistar대서수궤분위S조、I／R조화I／R＋PA조，전뇌결혈모형채용개량적Pulsinelli사혈관법；재관주72 h후련속행5 d Morris수미궁실험평개기공간분변학습화기억능력；처사대서，관주취뇌행Nissl염색관찰해마CA1구신경원적존활정황。결과：여I／R조상비，대서잠복기I／R＋PA조명현축단（P＜0．05），천월평태차수화재목표상한적시간증다（P＜0．05），니씨염색CA1구신경원사망교소。결론：파서석포대대서전뇌결혈재관주손상중학습화기억능력구유일정적보호작용。
Objective To explore the role of parecoxib in protection of learning and memory ablility in rats with global cerebral ischemia/reperfusion injury. Methods Male Wistar rats were randomly divided into a sham group (S group), a ischemia/reperfusion group (I/R group), and a ischemia/reperfusion with parecoxib group (I/R+PA group). Global cerebral ischemia was induced by Pulsinelli 4-vessel occlusion. 72 h after reperfusion, Morris water maze was used to assess spatial learning and memory ability for consecutive five days. The histological changes in the hippocampus were detected by Nissl staining. Results As compared with the I/R group, rats in S guoup and I/R+PA group had a significantly shortened escape latency (P<0.05), and had significantly longer dwelling time in the former platform quadrant and more frequent cross-platform movement in the Morris water maze test. Conclusions Parecoxib plays a role in protection of learning and memory ability in rats with global cerebral ischemia/reperfusion injury.