CAJ | 학술논문

目的：探讨C反应蛋白（CRP）及D－二聚体（D-Dimer）在慢性阻塞性肺疾病急性加重期（AECOPD）合并肺动脉高压（ PH ）患者中的临床意义及相关性。方法：150例AECOPD患者进行CRP、D-Dimer及动脉血气检测。结果：AECOPD合并中重度PH组患者CRP、D-Dimer、PaCO2水平高于轻度PH组及对照组，（P＜0．05），而PaO2水平低于轻度PH组及对照组（P＜0．05）。AECOPD合并轻度PH组患者CRP、D-Dimer水平高于对照组（P＜0．05）。 CRP、D-Dimer、PaCO2与肺动脉收缩压（PASP）呈正相关；PaO2与PASP呈负相关；CRP、D-Dimer 与 PaCO2呈正相关；CRP、D-Dimer 与 PaO2呈负相关。结论：CRP 及 D-Dimer 水平可作为AECOPD患者判断PH严重程度的指标。
목적：탐토C반응단백（CRP）급D－이취체（D-Dimer）재만성조새성폐질병급성가중기（AECOPD）합병폐동맥고압（ PH ）환자중적림상의의급상관성。방법：150례AECOPD환자진행CRP、D-Dimer급동맥혈기검측。결과：AECOPD합병중중도PH조환자CRP、D-Dimer、PaCO2수평고우경도PH조급대조조，（P＜0．05），이PaO2수평저우경도PH조급대조조（P＜0．05）。AECOPD합병경도PH조환자CRP、D-Dimer수평고우대조조（P＜0．05）。 CRP、D-Dimer、PaCO2여폐동맥수축압（PASP）정정상관；PaO2여PASP정부상관；CRP、D-Dimer 여 PaCO2정정상관；CRP、D-Dimer 여 PaO2정부상관。결론：CRP 급 D-Dimer 수평가작위AECOPD환자판단PH엄중정도적지표。
Objective To explore the clinical significance of C-reaction protein ( CRP ) and D-Dimer levels in patients with acute exacerbation of chronic obstructive pulmonary disease ( AECOPD ) complicated by pulmonary hypertension (PH) and their association with HP. Methods Arterial blood gas and levels of CRP and D-Dimer were detected in 150 patients with AECOPD. Results Levels of CRP, D-Dimer, and PaCO2 were higher but PO2 level was lower in patients with moderate to severe PH than those with mild PH and the control subjects. Levels of CRP and D-Dimer were higher in patients with mild PH than the control subjects. Levels of CRP, D-Dimer, and PCO2 levels had a linear relationship with PASP, while PO2 was negatively correlated with PASP. Levels of CRP and D-Dimer were positively related with PCO2, while were negatively correlated with PO2. Conclusions Levels of CRP and D-Dimer can be used as an indicator for estimating the severity of pulmonary hypertension in patients with AECOPD.